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Neurochemical Journal

, Volume 10, Issue 2, pp 120–130 | Cite as

Combined treatment with pantothenic acid derivatives and memantine alleviates scopolamine-induced amnesia in rats: The involvement of the thiol redox state and coenzyme A

  • M. Yu. Stepanichev
  • D. A. Markov
  • S. V. Freiman
  • O. A. Frolova
  • S. N. Omelyanchik
  • T. A. Borodina
  • M. R. Novikova
  • N. P. Kanunnikova
  • M. V. Onufriev
  • A. G. Moiseenok
  • N. V. GulyaevaEmail author
Experimental Articles
  • 45 Downloads

Abstract

Free-radical-mediated processes are involved in a variety of physiological events, while oxidative stress and related redox deregulation are implicated in various pathological events. Tripeptide glutathione plays an important role in the antioxidant defense of the brain, particularly in the maintenance of the optimal redox state in neurons and glial cells. We studied the combined effects of pantothenic acid derivatives, pantothenol and calcium pantothenate, and memantine, which is a glutamate receptor antagonist that is widely used for the treatment of dementia, on amnesia induced by scopolamine in rats. Scopolamine induced amnesia in rats; however, unexpectedly, this effect was even more expressed in the memantine-pretreated animals. Memory impairments were less manifested in the rats that were pretreated with memantine in combination with panthenol or calcium pantothenate. The detrimental scopolamine effect on memory was accompanied by significant depletions of glutathione and coenzyme A in the brain. While memantine recovered the glutathione status to some extent, it nevertheless further aggravated the scopolamine influence on coenzyme A levels. An alleviation of scopolamine-induced memory impairments that was observed after combined pretreatment with memantine and panthenol or calcium pantothenate was accompanied by a normalization of coenzyme A levels, while the effects on glutathione redox did not correlate with the behavioral data.

Keywords

brain redox regulation glutathione scopolamine-induced amnesia memantine hydrochloride pantothenic acid derivatives panthenol calcium pantothenate coenzyme A 

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Copyright information

© Pleiades Publishing, Ltd. 2016

Authors and Affiliations

  • M. Yu. Stepanichev
    • 1
  • D. A. Markov
    • 1
  • S. V. Freiman
    • 1
  • O. A. Frolova
    • 1
  • S. N. Omelyanchik
    • 2
  • T. A. Borodina
    • 2
  • M. R. Novikova
    • 1
  • N. P. Kanunnikova
    • 3
  • M. V. Onufriev
    • 1
  • A. G. Moiseenok
    • 2
  • N. V. Gulyaeva
    • 1
    Email author
  1. 1.Institute of Higher Nervous Activity and NeurophysiologyRussian Academy of SciencesMoscowRussia
  2. 2.Institute of Biochemistry of Biologically Active CompoundsGrodnoBelarus
  3. 3.Grodno State Medical UniversityGrodnoBelarus

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