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The expression of the TrkA and TrkB high-affinity neurotrophin receptors in the rat hippocampus after intracerebroventricular administration of Aβ(25–35)

Abstract

We studied the changes in the expression of high-affinity TrkA and TrkB receptors of the nerve-growth factor and brain-derived neurotrophic factor in the rat hippocampus at different time points after the administration of Aβ(25–35) into the lateral cerebral ventricles. Studies on TrkA and TrkB expression were performed using immunohistochemistry and the method of the real-time polymerase chain reaction. We found that intracerebroventricular administration of Aβ(25–35) to rats resulted in long-term alterations in the system of neurotrophic signaling in the hippocampus. Expression of the TrkA receptor increased 28 days after treatment, whereas expression of the TrkB receptor increased 12 days and then decreased by 28 days after the treatment. Thus, alterations in neurotrophin signaling may be involved in the mechanisms that are responsible for Aβ(25–35)-induced impairment of hippocampal functions in rats.

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References

  1. Iulita, M.F. and Cuello, A.C., Trends Pharmacol. Sci., 2014, vol. 35, no. 7, pp. 338–348.

    Article  CAS  PubMed  Google Scholar 

  2. Fahnestock, M., Michalski, B., Xu, B., and Coughlin, M.D., Mol. Cell. Neurosci., 2001, vol. 18, no. 2, pp. 210–220.

    Article  CAS  PubMed  Google Scholar 

  3. Kew, J.N., Smith, D.W., and Sofroniew, M.V., Neuroscience, 1996, vol. 70, no. 2, pp. 329–339.

    Article  CAS  PubMed  Google Scholar 

  4. Li, Y., Holtzman, D.M., Kromer, L.F., Kaplan, D.R., Chua-Couzens, J., Clary, D.O., Knüsel, B., and Mobley, W.C., J. Neurosci., 1995, vol. 15, no. 4, pp. 2888–2905.

    CAS  PubMed  Google Scholar 

  5. Sofroniew, M.V., Galletly, N.P., Isacson, O., and Svendsen, C.N., Science, 1990, vol. 247, no. 4940, pp. 338–342.

    Article  CAS  PubMed  Google Scholar 

  6. Kordower, J.H., Chen, E.Y., Sladek, J.R., Jr., and Mufson, E.J., J. Comp. Neurol., 1994, vol. 349, no. 1, pp. 20–35.

    Article  CAS  PubMed  Google Scholar 

  7. Conner, J.M., Franks, K.M., Titterness, A.K., Russell, K., Merrill, D.A., Christie, B.R., Sejnowski, T.J., and Tuszynski, M.H., J. Neurosci., 2009, vol. 29, no. 35, pp. 10883–10889.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  8. Ginsberg, S.D., Che, S., Wuu, J., Counts, S.E., and Mufson, E.J., J. Neurochem., 2006, vol. 97, no. 2, pp. 475–487.

    Article  CAS  PubMed  Google Scholar 

  9. Mufson, E.J., Li, J.M., Sobreviela, T., and Kordower, J.H., Neuroreport, 1996, vol. 8, no. 1, pp. 25–29.

    Article  CAS  PubMed  Google Scholar 

  10. Boissiere, F., Faucheux, B., Ruberg, M., Agid, Y., and Hirsch, E.C., Exp. Neurol., 1997, vol. 145, no. 1, pp. 245–252.

    Article  CAS  PubMed  Google Scholar 

  11. Peng, S., Wuu, J., Mufson, E.J., and Fahnestock, M., J. Neuropathol. Exp. Neurol., 2004, vol. 63, no. 6, pp. 641–649.

    CAS  PubMed  Google Scholar 

  12. Mufson, E.J., He, B., Nadeem, M., Perez, S.E., Counts, S.E., Leurgans, S., Fritz, J., Lah, J., Ginsberg, S.D., Wuu, J., and Scheff, S.W., J. Neuropathol. Exp. Neurol., 2012, vol. 71, no. 11, pp. 1018–1029.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  13. Schliebs, R. and Arendt, T., Behav. Brain Res., 2011, vol. 221, no. 2, pp. 555–563.

    Article  CAS  PubMed  Google Scholar 

  14. Nitsch, R.M., Slack, B.E., Wurtman, R.J., and Growdon, J.H., Science, 1992, vol. 258, no. 5080, pp. 304–307.

    Article  CAS  PubMed  Google Scholar 

  15. Kuznetsova, E. and Schliebs, R., Curr. Pharm. Des., 2013, vol. 19, no. 38, pp. 6749–6765.

    Article  CAS  PubMed  Google Scholar 

  16. O’Mahony, S., Harkany, T., Rensink, A.A., Abraham, I., De Jong, G.I., Varga, J.L., Zarandi, M., Penke, B., Nyakas, C., Luiten, P.G., and Leonard, B.E., Brain Res. Bull., 1998, vol. 45, no. 4, pp. 405–411.

    Article  PubMed  Google Scholar 

  17. Maurice, T., Lockhart, B.P., and Privat, A., Brain Res., 1996, vol. 706, no. 2, pp. 181–193.

    Article  CAS  PubMed  Google Scholar 

  18. Yamaguchi, Y. and Kawashima, S., Eur. J. Pharmacol., 2001, vol. 412, no. 3, pp. 265–272.

    Article  CAS  PubMed  Google Scholar 

  19. Giovannelli, L., Casamenti, F., Scali, C., Bartolini, L., and Pepeu, G., Neuroscience, 1995, vol. 66, no. 4, pp. 781–792.

    Article  CAS  PubMed  Google Scholar 

  20. Stepanichev, M., Lazareva, N., Tukhbatova, G., Salozhin, S., and Gulyaeva, N., Behav. Brain Res., 2014, vol. 259, pp. 152–157.

    Article  CAS  PubMed  Google Scholar 

  21. Paxinos, G. and Watson, C., The Rat Brain in Stereotaxic Coordinates, 1982, Sidney: Academic Press.

    Google Scholar 

  22. Gibbs, R.B. and Pfaff, D.W., J. Comp. Neurol., 1994, vol. 341, no. 3, pp. 324–339.

    Article  CAS  PubMed  Google Scholar 

  23. Park, I.K., Hou, X., Lee, K.Y., Park, O.S., Lee, K.Y., Kim, M.Y., Min, T.S., Lee, G.J., Kim, W.S., and Kim, M.K., J. Vet. Sci., 2004, vol. 5, no. 4, pp. 303–307.

    PubMed  Google Scholar 

  24. Holtzman, D.M., Kilbridge, J., Li, Y., Cunningham, E.T., Jr., Lenn, N.J., Clary, D.O., Reichardt, L.F., and Mobley, W.C., J. Neurosci., 1995, vol. 15, no. 2, pp. 1567–1576.

    PubMed Central  CAS  PubMed  Google Scholar 

  25. Toyoda, A., Iio, W., Goto, T., Koike, H., and Tsukahara, T., Anim. Sci. J., 2014.

    Google Scholar 

  26. Bulbarelli, A., Lonati, E., Cazzaniga, E., Re, F., Sesana, S., Barisani, D., Sancini, G., Mutoh, T., and Masserini, M., Mol. Cell. Neurosci., 2009, vol. 40, no. 3, pp. 365–373.

    Article  CAS  PubMed  Google Scholar 

  27. Stepanichev, M.Yu., Onufriev, M.V., Mitrokhina, O.S., Moiseeva, Yu.V., Lazareva, N.A., Viktorov, I.V., and Gulyaeva, N.V., Neirokhimiya, 2000, vol. 17, no. 4, pp. 291–306.

    Google Scholar 

  28. Aliaga, E., Silhol, M., Bonneau, N., Maurice, T., Arancibia, S., and Tapia-Arancibia, L., Neurobiol. Dis., 2010, vol. 37, no. 1, pp. 208–217.

    Article  CAS  PubMed  Google Scholar 

  29. Poon, W.W., Carlos, A.J., Aguilar, B.L., Berchtold, N.C., Kawano, C.K., Zograbyan, V., Yaopruke, T., Shelanski, M., and Cotman, C.W., J. Biol. Chem., 2013, vol. 288, no. 23, pp. 16937–16948.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

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Correspondence to M. Yu. Stepanichev.

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Original Russian Text © M.Yu. Stepanichev, A.O. Tishkina, N.A. Lazareva, E.K. Mart’yanova, G.R. Tukhbatova, A.O. Kulagina, S.V. Salozhin, N.V. Gulyaeva, 2015, published in Neirokhimiya, 2015, Vol. 32, No. 1, pp. 57–63.

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Stepanichev, M.Y., Tishkina, A.O., Lazareva, N.A. et al. The expression of the TrkA and TrkB high-affinity neurotrophin receptors in the rat hippocampus after intracerebroventricular administration of Aβ(25–35). Neurochem. J. 9, 47–53 (2015). https://doi.org/10.1134/S1819712415010110

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  • DOI: https://doi.org/10.1134/S1819712415010110

Keywords

  • amyloid-beta
  • nerve growth factor
  • brain-derived neurotrophic factor
  • TrkA
  • TrkB
  • hippocampus
  • Alzheimer’s disease