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Serum iron metabolism markers including hepcidin in multiple sclerosis patients

  • Clinical Neurochemistry
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Abstract

The impact and pathogenesis of iron accumulation in multiple sclerosis (MS) is not yet clear. In this study, we investigated serum markers of iron metabolism, namely iron, ferritin, transferrin, total iron binding capacity (TIBC), and hepcidin in patients with MS, and compared to a healthy control group. Thirty-five stable relapse remitting MS patients (15 males and 20 females; mean age 38 ± 11 years) and thirty-five age-sex matched healthy controls (13 males and 22 females; mean age 38 ± 10 years) were included in this study. All patients were diagnosed with MS, according to the criteria of McDonald. Serum transferrin and TIBC levels were significantly lower (p = 0.02 and p = 0.03, respectively), whereas hepcidin, iron and ferritin values did not show any significant difference (p = 0.8, p = 0.2 and p = 0.8, respectively) in patients with MS compared to controls. There was no statistically significant correlation between iron metabolism markers and disease duration, Expanded Disability Status Scale and progression index. Our results were as expected from a chronic disease; thus were in favor of local, rather than a systemic impairment in iron metabolism in these patients. Our study, contributes to the establishment of further hypotheses on the role of hepcidin and iron metabolism in MS.

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References

  1. Kingwell, E., Marriott, J.J., Jetté, N., Pringsheim, T., et al., BMC Neurol., 2013, vol. 26, no. 13, p. 128.

    Article  Google Scholar 

  2. Compston, A. and Coles, A., Lancet, 2002, vol. 359, pp. 1221–1231.

    Article  PubMed  Google Scholar 

  3. Al-Radaideh, A.M., Wharton, S.J., Lim, S.Y., Tench, C.R., et al., Mult. Scler., 2013, vol. 19, no. 7, pp. 896–903.

    Article  PubMed  Google Scholar 

  4. Bagnato, F., Hametner, S., Yao, B., van Gelderen, P., et al., Brain, 2011, vol. 34, no. 12, pp. 602–615.

    Google Scholar 

  5. Stankiewicz, J., Panter, S.S., Neema, M., Arora, A., et al., Neurotherapeutics, 2007, vol. 4, pp. 371–386.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  6. Sullivan JL., J. Lab. Clin. Med., 2004, vol. 144, pp. 280–284.

    Article  CAS  PubMed  Google Scholar 

  7. Sadowska-Bartosz, I., Adamczyk-Sowa, M., Galiniak, S., Mucha, S., et al., Neurochem. Int., 2013, vol. 63, no. 5, pp. 507–516.

    Article  CAS  PubMed  Google Scholar 

  8. Stankiewicz, J.M. and Brass, S.D., Curr. Opin. Clin. Nutr. Metab. Care, 2009, vol. 12, pp. 22–29.

    Article  CAS  PubMed  Google Scholar 

  9. LeVine, S.M., and Chakrabarty, A., Ann. N.Y. Acad. Sci., 2004, vol. 1012, pp. 252–266.

    Article  CAS  PubMed  Google Scholar 

  10. Ganz, T., Olbina, G., Girelli, D., Nemeth, E., et al., Blood, 2008, vol. 112, pp. 4292–4297.

    Article  CAS  PubMed  Google Scholar 

  11. Guido, D’Angelo, Blood Res., 2013, vol. 48, pp. 10–15.

    Article  Google Scholar 

  12. Polman, C.H., Reingold, S.C., Banwell, B., Clanet, M., et al., Ann. Neurol., 2011, vol. 69, no. 2, pp. 292–302.

    Article  PubMed Central  PubMed  Google Scholar 

  13. Kurtzke, J.F., Neurology, 1983, vol. 33, pp. 1444–1452.

    Article  CAS  PubMed  Google Scholar 

  14. Crichton, R.R., Dexter, D.T., and Ward, R.J., J. Neural. Transm., 2011, vol. 118, pp. 301–314.

    Article  CAS  PubMed  Google Scholar 

  15. Crichton, R.R., Dexter, D.T., and Ward, R.J., Coord. Chem. Rev., 2008, vol. 252, pp. 1189–1199.

    Article  CAS  Google Scholar 

  16. Zivadinov, R., Schirda, C., Dwyer, M.G., Haacke, M.E., et al., Int. Angiol., 2010, vol. 29, pp. 158–175.

    CAS  PubMed  Google Scholar 

  17. Neema, M., Arora, A., Healy, B.C., Guss, Z.D., et al., J. Neuroimaging, 2009, vol. 19, pp. 3–8.

    Article  PubMed Central  PubMed  Google Scholar 

  18. Brass, S.D., Benedict, R.H., Weinstock-Guttman, B., Munschauer, F., et al., Mult. Scler., 2006, vol. 12, pp. 437–444.

    Article  CAS  PubMed  Google Scholar 

  19. Tjoa, C.W., Benedict, R.H., Weinstock-Guttman, B., Fabiano, A.J., et al., J. Neurol. Sci., 2005, vol. 234, pp. 17–24.

    Article  CAS  PubMed  Google Scholar 

  20. LeVine, S.M., Lynch, S.G., Ou, C.N., Wulser, M.J., et al., Brain Res., 1999, vol. 821, no. 2, pp. 511–515.

    Article  CAS  PubMed  Google Scholar 

  21. Worthington, V., Killestein, J., Eikelenboom, M.J., et al., Neurology, 2010, vol. 75, no. 18, pp. 1617–1622.

    Article  CAS  PubMed  Google Scholar 

  22. Petzold, A., Eikelenboom, M.J., Gveric, D., et al., Brain, 2002, vol. 125, no. 7, pp. 1462–1473.

    Article  CAS  PubMed  Google Scholar 

  23. Sfagos, C., Makis, A.C., Chaidos, A., et al., Mult. Scler., 2005, vol. 11, no. 3, pp. 272–275.

    Article  CAS  PubMed  Google Scholar 

  24. Abo-Krysha, N. and Rashed, L., Mult. Scler., 2008, vol. 14, no. 5, pp. 602–608.

    Article  CAS  PubMed  Google Scholar 

  25. Rejdak, K., Petzold, A., Stelmasiak, Z., and Giovannoni, G., Mult. Scler., 2008, vol. 14, no. 1, pp. 59–66.

    Article  CAS  PubMed  Google Scholar 

  26. Zeman, D., Adam, P., Kalistova, Â.H., Sobek, O., et al., Acta Neurol. Scand., 2000, vol. 101, pp. 89–94.

    Article  CAS  PubMed  Google Scholar 

  27. Gabay, C. and Kushner, I., N. Engl. J. Med., 1999, vol. 340, pp. 448–454.

    Article  CAS  PubMed  Google Scholar 

  28. Double, K.L., Gerlach, M., Youdim, M.B., and Riederer, P., J. Neural. Transm. Suppl., 2000, vol. 60, no. 29, pp. 37–58.

    PubMed  Google Scholar 

  29. Naziroglu, M., Kutluhan, S., Ovey, I.S., Aykur, M., et al., Nutr. Neurosci., 2013 (in press).

    Google Scholar 

  30. Gemmati, D., Zeri, G., Orioli, E., De Gaetano, F.E., et al., BMC Med. Gen., 2012, vol. 13, p. 70.

    Article  CAS  Google Scholar 

  31. Zechel, S., Huber-Wittmer, K., and von Bohlen und Halbach, O., J. Neurosci. Res., 2006, vol. 84, pp. 790–800.

    Article  CAS  PubMed  Google Scholar 

  32. Wang S.M., Fu L.J., Duan X.L., et al., Cell. Mol. Life Sci., 2010, vol. 67, pp. 123–133.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Central Laboratories of Antalya Education and Research Hospital of Ministry of Health, Varlik Mahallesi Kazim Karabekir Caddesi Soguksu, TR-07100, Antalya, Turkey

    Hamit yasar Ellidag, Necat Yılmaz & Aslı Bayındır

  2. Neurology Clinic of Antalya Education and Research Hospital of Ministry of Health, Antalya, Turkey

    Fatma Kurtulus & Aylin Yaman

  3. Antalya Public Health Center of Ministry of Health, Antalya, Turkey

    Esin Eren

  4. Batman Maternity and Children’s Hospital, Batman, Turkey

    Ozgur Aydin

Authors
  1. Hamit yasar Ellidag
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  2. Fatma Kurtulus
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  3. Aylin Yaman
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  4. Esin Eren
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  5. Necat Yılmaz
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  6. Ozgur Aydin
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  7. Aslı Bayındır
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Correspondence to Hamit yasar Ellidag.

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Ellidag, H.y., Kurtulus, F., Yaman, A. et al. Serum iron metabolism markers including hepcidin in multiple sclerosis patients. Neurochem. J. 8, 226–230 (2014). https://doi.org/10.1134/S1819712414030040

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  • DOI: https://doi.org/10.1134/S1819712414030040

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