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Neurochemical Journal

, Volume 7, Issue 4, pp 256–265 | Cite as

The role of noradrenalin in the pathogenesis of primary headaches

  • A. Y. SokolovEmail author
  • O. A. Lyubashina
  • A. V. Amelin
  • S. S. Panteleev
Review Articles

Abstract

This review is focused on the role of noradrenalin and its receptors in the pathogenesis of primary headaches, in particular, migraine headaches. The data are summarized on the involvement of different adrenoreceptors in the regulation of tone of cerebral vessels and modulation of transmission of nociceptive information in the trigeminovascular system and at the supraspinal level of the CNS. We discuss the pharmacodynamics of several adrenergic drugs that are used for prophylactic treatment of migraine headaches.

Keywords

noradrenalin adrenoceptors headache migraine trigeminal nerve endogenous antinociceptive system 

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Copyright information

© Pleiades Publishing, Ltd. 2013

Authors and Affiliations

  • A. Y. Sokolov
    • 1
    • 2
    • 4
    Email author
  • O. A. Lyubashina
    • 1
  • A. V. Amelin
    • 3
  • S. S. Panteleev
    • 1
    • 2
  1. 1.Pavlov Institute of PhysiologyRussian Academy of SciencesSt. PetersburgRussia
  2. 2.Valdman Institute of PharmacologyFirst Pavlov State Medical UniversitySt. PetersburgRussia
  3. 3.Department of Neurology and NeurosurgeryFirst Pavlov State Medical UniversitySt. PetersburgRussia
  4. 4.St. PetersburgRussia

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