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Involvement of the 5-HT1A and 5-HT2A/2C serotonin receptors in the anxious behavior of prenatally stressed ovariectomized rats

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Abstract

We compared the effects of an antagonist of 5-HT1A receptors, NAN-190 (0.1 mg/kg intraperitoneally), and an antagonist of 5-HT2A/2C receptors, ketanserin (0.1 mg/kg intraperitoneally), which were chronically injected for 14 days, on the anxiety level in prenatally stressed female rats with an ovariectomyinduced experimental deficiency of estrogens. Chronic administration of ketanserin to ovariectomized prenatally stressed females had an anxiolytic effect and corrected disturbed levels of follitropin, lutropin, and estradiol. Administration of NAN-190 to ovariectomized prenatally stressed rats increased the anxiety level and decreased the ratio between the levels of tropic and peripheral sex hormones.

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Authors and Affiliations

  1. Laboratory of Endocrinology, Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia

    Yu. O. Fedotova, S. G. Pivina & N. E. Ordyan

  2. nab. Makarova 6, St. Petersburg, 199034, Russia

    Yu. O. Fedotova

Authors
  1. Yu. O. Fedotova
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  2. S. G. Pivina
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  3. N. E. Ordyan
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Correspondence to Yu. O. Fedotova.

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Original Russian Text © Yu.O. Fedotova, S.G. Pivina, N.E. Ordyan, 2012, published in Neirokhimiya, 2012, Vol. 29, No. 4, pp. 335–339.

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Fedotova, Y.O., Pivina, S.G. & Ordyan, N.E. Involvement of the 5-HT1A and 5-HT2A/2C serotonin receptors in the anxious behavior of prenatally stressed ovariectomized rats. Neurochem. J. 6, 307–310 (2012). https://doi.org/10.1134/S1819712412040071

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  • DOI: https://doi.org/10.1134/S1819712412040071

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