Skip to main content
SpringerLink
Log in

The effects of protein kinase C inhibitors on the contents of several transcription and apoptosis modulating factors in the spinal cords of rats with diabetic neuropathy

  • Experimental Articles
  • Published:
Neurochemical Journal Aims and scope Submit manuscript

Abstract

We studied changes in the contents of the transcription factors NF-kB and Fos, the apoptosis regulating factors bax and bcl-xl, and a marker of astroglial activity, viz., the glial fibrillar acidic protein, in the spinal cords of rats with experimental streptozotocin-induced diabetes. We found that shifts in the levels of these factors after induction of diabetes may be partially prevented by administration of the protein kinase C (PKC) inhibitors chelerythrine hydrochloride and rottlerin. Our data show that these substances are promising drugs for the correction of diabetic neuropathy. PKC isoenzymes contribute to pathogenesis of diabetic neuropathy differently; therefore, the development of selective inhibitors for specific PKC isoenzymes may improve their efficacy and decrease the probability of the appearance of side effects.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Bansal, V., Kalita, J., and Misra, U.K., Postgrad. Med. J., 2006, vol. 82, pp. 95–100.

    Article  PubMed  CAS  Google Scholar 

  2. Pieper, G.M., Riaz-Ul-Haq J., Cardiovasc. Pharmacology, 1997, vol. 30, pp. 528–532.

    Article  CAS  Google Scholar 

  3. Catley, M.C., Cambridge, L.M., Nasuhara, Y., Ito, K., Chivers, J.E., Beaton, A., Holden, N.S., Bergmann, M.W., Barnes, P.J., and Newton, R., J. Biol. Chem., 2004, vol. 279, no. 18, pp. 18457–18466.

    Article  PubMed  CAS  Google Scholar 

  4. Koya, D. and King, G.L., Diabetes, 1998, vol. 47, pp. 859–866.

    Article  PubMed  CAS  Google Scholar 

  5. He, Z. and King, G.L., Circulation, 2004, vol. 110, pp. 7–9.

    Article  PubMed  Google Scholar 

  6. Frank, R.N., Am. J. Ophthalmol., 2002, vol. 133, no. 5, pp. 693–698.

    Article  PubMed  CAS  Google Scholar 

  7. Wakasaki, H., Koya, D., and Schoen, F.J., Proc. Natl. Acad. Sci. USA, 1997, vol. 94, pp. 9320–9325.

    Article  PubMed  CAS  Google Scholar 

  8. Mima, A., Ohshiro, Y., Kitada, M., Matsumoto, M., Geraldes, P., Li, C., Li, Q., White, G.S., Cahill, C., Rask-Madsen, C., and King, G.L., Kidney Int., 2011, vol. 79, no. 8, pp. 883–896.

    Article  PubMed  CAS  Google Scholar 

  9. Eichberg, J., Int. Rev. Neurobiol., 2002, vol. 80, pp. 61–82.

    Article  Google Scholar 

  10. Vartanyan, G.S. and Alaverdyan, A.R., Neirokhimiya, 2009, vol. 29, no. 1, pp. 19–28.

    Google Scholar 

  11. Hunt, S.P., Pini, A., and Evan, G., Nature, 1987, vol. 328, no. 6131, pp. 632–634.

    Article  PubMed  CAS  Google Scholar 

  12. Munglani, R. and Hunt, S.P., Br. J. Anaest., 1995, vol. 75, no. 2, pp. 186–192.

    CAS  Google Scholar 

  13. Morgado, C. and Tavares, I., Diabetes Metab. Res. Rev., 2007, vol. 23, no. 8, pp. 644–652.

    Article  PubMed  CAS  Google Scholar 

  14. Feng, M.H., Wan, W.L., Bing, C.C., Chien, M.C., Chia-Ron, Y., Lian, Y.L., and Chih, C.L., Shing, H.L., Chiau, S.L., Cell Signal., 2006, vol. 18, pp. 391–399.

    Article  Google Scholar 

  15. Ji, R.R., Kawasaki, Y., Zhuang, Z.Y., Wen, Y.R., and Decosterd, I., Neuron Glia Biol., 2006, vol. 2, no. 4, pp. 259–269.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Yerevan State Medical University, Yerevan, Republic of Armenia

    A. R. Alaverdyan & G. S. Vartanyan

  2. ul. Koryuna, 2, Yerevan, 1005, Republic of Armenia

    A. R. Alaverdyan

Authors
  1. A. R. Alaverdyan
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. G. S. Vartanyan
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to A. R. Alaverdyan.

Additional information

Original Russian Text © A.R. Alaverdyan, G.S. Vartanyan, 2012, published in Neirokhimiya, 2012, Vol. 29, No. 3, pp. 235–239.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Alaverdyan, A.R., Vartanyan, G.S. The effects of protein kinase C inhibitors on the contents of several transcription and apoptosis modulating factors in the spinal cords of rats with diabetic neuropathy. Neurochem. J. 6, 223–226 (2012). https://doi.org/10.1134/S1819712412030026

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S1819712412030026

Keywords

Search

Navigation