Abstract
Oxidative protein modification (OPM) was studied in the striatum, hippocampus, and hypothalamus of rats of various ages that were subjected to prenatal stress. The basal level of spontaneous OPM products and the level of OPM products after induction by Fenton’s reagent were measured. The OPM processes in the structures we studied had similar features. Under normal conditions, a gradual increase in the content of OPM products was observed at days 10–30 of postnatal ontogeny and a decrease in this index was observed in adult animals. Additionally, some differences in the contents of OPM products were revealed in specific brain regions. In the animals that were subjected to prenatal stress, we found substantial differences in the time course of OPM in all brain regions studied. Thus, the level of OPM products in 10-day-old rats that were subjected to prenatal stress was substantially higher compared to that in the control rats. However, the indices of both spontaneous and induced OPM later decreased. Thus, impairments of OPM processes in the striatum, hypothalamus, and hippocampus may be a cause of changes in adaptive behavior, which were observed in adult rats that were subjected to prenatal stress.
Similar content being viewed by others
References
Welbey, L.A. and Secki, I.R., Neuroendocrinol., 2001, vol. 1, no. 4, pp.1147–1156.
Shanks, N., Windle, R.I., Perks, P.A., et al., Proc. Natl. Acad. Sci. USA, 2000, vol. 97, no. 22, pp. 5645–5650.
Shalyapina, V.G., Zaichenko, I.N., Ordyan, N.E., and Batuev, A.S., Ross. Fiziol. Zhurn. im. I.M. Sechenova, 2001, vol. 57, no. 9, pp. 1193–1201.
Otellin, V.A., Khozhai, L.I., and Ordyan, N.E., Prenatal’nye stressornye vozdeistviya i razvivayushchiisya mozg (Prenatal Stress Influences and Developing Brain), St. Petersburg: Izd-vo “Desyatka”, 2007.
Ugryumov, M.V., Mekhanizmy neiroendokrinnoi regulyatsii (Mechanisms of Neuroendocrine Regulation), Moscow: Nauka, 1999.
Anokhin, P.K., Ocherki po fiziologii funktsional’nykh sistem (The Essays on Physiology of Functional Systems), Moscow: Meditsina, 1975.
Eshchenko, N.D., Energetic metabolism of the brain, in Neirokhimiya (Neurochemistry), St. Petersburg: Izd-vo SPbGU, 1996.
V’yushina, A.V. and Pritvorova, A.V., Abstracts of Papers, Vserossiiskaya konferentsiya “Neiroendokrinologiya 2005” (All-Russian Conference “Neuroendocrinology 2005”), St. Petersburg, 2005, p. 31.
Stroev, S.A. and Samoilov, M.O., Endogennye antioksidanty i gipoksicheskaya tolerantnost’ mozga (Endogenous Antioxidants and Hypoxic Tolerance of the Brain), St. Petersburg: Institut Fiziologii im. I.P. Pavlova RAN, 2006.
Reinheckel, T., Noack, H., Lorenz, S., et al., Free Rad. Res., 1998, vol. 29, no. 4, pp. 464–478.
Flerov, M.A., Gerasimova, I.A., and Shalyapina, V.G., Neirokhimiya, 2004, vol. 21, no. 1, pp. 52–57.
Dmitrieva, N.I., Zh. Evol. Biokhim. Fiziol., 1981, vol. 17, no. 3, pp. 287–292.
Pigareva, Z.D., Biokhimiya razvivayushchegosya mozga, (Biochemistry of the Developing Brain), Moscow: Meditsina, 1972.
Levin, R.L., Garland, D., Oliver, C.N., et al., Methods Enzymol., 1990, vol. 186, pp. 464–478.
Dubinina, E.E., Morozova, M.G., Leonova, N.V., Gamper, N.L., Soliternova, I.B., Nuller, Yu.L., Butoma, G.B., and Kovrugina, S.V., Vopr. Med. Khim., 2000, vol. 46, no. 4, pp. 102–112.
Dubinina, E.E., Vopr. Med. Khim., 2001, vol. 47, no. 6, pp. 561–581.
Kuz’menko, D.I. and Laptev, B.I., Vopr. Med. Khim., 1999, vol. 45, no. 1, pp. 47–54.
Lushchak, V.I., Biokhimiya, 2007, vol. 72, no. 8, pp. 995–1016.
Dubinina, E.E., Produkty metabolizma kisloroda v funktsional’noi aktivnosti kletok (Products of Oxygen Metabolism in Functional Activity of Cells), St. Petersburg: Meditsinskaya pressa, 2006.
Sudakov, K.V., Usp. Fiziol. Nauk, 1996, vol. 27, no. 2, pp. 3–23.
O’Connor, T.G., Heron, J., Golding, J., Beveridge, M., and Glover, V., Br. J. Psychiatry, 2002, vol. 180, pp. 502–508.
Ordyan, N.E. and Pivina, S.G., Ros. Fiziol. Zhurn. im. I.M. Sechenova, 2003, vol. 84, no. 1, pp. 52–59.
Piontkovskii, I.A., Funktsiya i struktura mozga zhivotnogo, obluchennogo ioniziruyushchei radiatsiei v antenatal’nom periode (Function and Structure of the Brain of an Animal Subjected to Ionizing Irradiation in Antenatal Period), Moscow: Nauka, 1964.
Semagin, V.N. and Antipov, V.V., Kompensatornye vozmozhnosti vysshei nervnoi deyatel’nosti pri obluchenii embrionov (Compensatory Abilities of Higher Nervous Activity after Irradiation of Embryos), Moscow: Nauka, 1978.
Flerov, M.A., Gerasimova, I.A., and V’yushina, A.V., Neirokhimiya, 2005, vol. 22, no. 2, pp. 102–107.
V’yushina, A.V. and Pritvorova, A.V., Abstracts of Papers, Fiziologiya cheloveka i zhivotnykh: ot eksperimenta k klinicheskoi praktike (Physiology of a Human and Animals: from Experiment to Clinical Practice), Syktyvkar, 2005, p. 11.
V’yushina, A.V., Gerasimova, I.A., and Flerov, M.A., Byull. Eksperim. Biol. Med., 2004, vol. 138, no. 7, pp. 41–44.
Korochkin, L.I. and Mikhailov, A.T., Vvedenie v neirogenetiku, (Introduction to Neurogenetics), Moscow: Nauka, 2000.
Shamolina, T.S., Pivina, S.G., and Ordyan, N.E., Ros. Fiziol. Zhurn. Im. I.M. Sechenova, 2009, vol. 95, no. 9, pp. 984–992.
Vallee, M., Maccari, S., Dellu, F.E., Simon, H., Moal, M., and Mayo, W., Eur. J. Neurosci., 1999, vol. 11, p. 2906–2916.
Author information
Authors and Affiliations
Corresponding author
Additional information
Original Russian Text © A.V. V’yushina, A.V. Pritvorova, M.A. Flerov, 2012, published in Neirokhimiya, 2012, Vol. 29, No. 3, pp. 240–246.
Rights and permissions
About this article
Cite this article
V’yushina, A.V., Pritvorova, A.V. & Flerov, M.A. The effect of prenatal stress on oxidative protein modification in the rat brain in ontogeny. Neurochem. J. 6, 227–232 (2012). https://doi.org/10.1134/S1819712412020110
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1134/S1819712412020110