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Types of bioinformatic programs in the continuum of regulatory peptides and non-peptide mediators. Traits of interaction of dopamine and serotonin systems

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Abstract

We analyzed a complex multilevel network of the induction links of regulatory peptides and nonpeptide mediators on the basis of a database that was created using data obtained in 1970–2010 on the physiological and induction effects of these regulators. We determined models of bioinformatic programs that exist inside a continuum of regulatory peptides and mediators. They helped us to understand the main principles of the functioning of various endogenous compounds and to visualize the channels of directed therapeutic control of biological processes. We found the traits of the system of coupled functioning of serotonin and dopamine at several different physiological levels, which designated the nature of the resulting vectors of the two mediators.

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References

  1. Ashmarin, I.P. and Obukhova, M.F., Vestnik RAMN, 1994, no. 10, pp. 28–34.

  2. Koroleva, S.V. and Ashmarin, I.P., Journal of Theoretical Biology, 2002, vol. 216, no. 3, pp. 257–271.

    Article  PubMed  CAS  Google Scholar 

  3. Koroleva, S.V. and Ashmarin, I.P., Bioorg. Khim., 2006, vol. 32, no. 3, pp. 249–257.

    PubMed  CAS  Google Scholar 

  4. Ashmarin, I.P. and Koroleva, S.V., Dizregulyatsionnaya patologiya nervnoi sistemy., Gusev, E.I and Kryzhanovskii, G.N, Ed., Moscow: Meditsinskoe informatsionnoe agenstvo, 2009.

    Google Scholar 

  5. Koroleva, S.V., Issledovanie strukturno-funktsional’nykh osobennostei kontinuuma regulyatornykh peptidov i mediatorov:, Doctoral (Biol) Dissertation, Moscow: MGU., 2010.

    Google Scholar 

  6. Koroleva, S.V. and Ashmarin, I.P., Patogenez, 2005, vol. 3, no. 3, pp. 11–15.

    Google Scholar 

  7. Koroleva, S.V., Nikolaeva, A.A., and Ashmarin, I.P., Izvestiya Akademii Nauk, Seriya Biologicheskaya, 2006, no. 4, pp. 457–469.

  8. Nikolaeva, A.A., Koroleva, S.V., and Ashmarin, I.P., Neirokhimiya, 2008, vol. 25, no. 3, pp. 191–201.

    CAS  Google Scholar 

  9. Elvander, E. and Ogren, S.O., Neuropeptides, 2005, vol. 39, no. 3, pp. 245–248.

    Article  PubMed  CAS  Google Scholar 

  10. Ogren, S.O., Pramanik, A., Land, T., and Langel, U., Eur. J. Pharmacol., 1993, vol. 242, no. 1, pp. 59–64.

    Article  PubMed  CAS  Google Scholar 

  11. Akehira, K., Nakane, Y., Hioki, K., and Taniyama, K., Eur. J. Pharmacol., 1995, vol. 284, nos. 1–2, pp. 149–155.

    Article  PubMed  CAS  Google Scholar 

  12. Nishimura, T. and Akasu, T., Kurume Med. J., 1995, vol. 42, no. 1, pp. 45–48.

    Article  PubMed  CAS  Google Scholar 

  13. Smith-White, M.A., Iismaa, T.P., and Potter, E.K., Br. J. Pharmacol., 2003, vol. 140, no. 1, pp. 170–178.

    Article  PubMed  CAS  Google Scholar 

  14. Pérez-Navarro, E., Alberch, J., and Marsal, J., Int. J. Dev. Neurosci., 1993, vol. 11, no. 6, pp. 701–708.

    Article  PubMed  Google Scholar 

  15. Hasenöhrl, R.U., Souza-Silva, M.A., Nikolaus, S., Tomaz, C., Brandao, M.L., Schwarting, R.K., and Huston, J.P., Neuropeptides, 2000, vol. 34, no. 5, pp. 272–280.

    Article  PubMed  Google Scholar 

  16. Lapchak, P.A., Araujo, D.M., Quirion, R., and Beaudet, A., J. Neurochem., 1990, vol. 55, no. 4, pp. 1397–1403.

    Article  PubMed  CAS  Google Scholar 

  17. Torocsik, A., Rakovska, A., Gorcs, T., and Vizi, E.S., Brain Res., 1993, vol. 612, nos. 1–2, pp. 306–312.

    Article  PubMed  CAS  Google Scholar 

  18. Magnani, M., Mantovani, P., and Pepeu, G., Neuropharmacology, 1984, vol. 23, no. 11, pp. 1305–1309.

    Article  PubMed  CAS  Google Scholar 

  19. Soudah, H.C., Lu, Y., Hasler, W.L., and Owyang, C., Am. J. Physiol., 1992, vol. 263, no. 1, pp. G102–107.

    PubMed  CAS  Google Scholar 

  20. Arneric-, S.P. and Reis, D.J., Brain Res., 1986, vol. 374, no. 1, pp. 153–161.

    Article  PubMed  CAS  Google Scholar 

  21. Wood, P.L., Cheney, D.L., and Costa, E., J. Pharmacol. Exp. Ther., 1979, vol. 209, no. 1, pp. 97–103.

    PubMed  CAS  Google Scholar 

  22. Schoffelmeer, A.N., Warden, G., Hogenboom, F., and Mulder, A.H., J. Pharmacol. Exp. Ther., 1991, vol. 258, no. 1, pp. 237–242.

    PubMed  CAS  Google Scholar 

  23. Yokotani, K. and Osumi, Y., Jpn. J. Pharmacol, 1998, vol. 78, no. 1, pp. 93–95.

    Article  PubMed  CAS  Google Scholar 

  24. Hiramatsu, M., Murai, M., and Kameyama, T., Biochem. Pharmacol., 1999, vol. 57, no. 11, pp. 1321–1329.

    Article  PubMed  CAS  Google Scholar 

  25. Oron, L., Sarne, Y., and Michaelson, D.M., Neurosci. Let., 1991, vol. 125, no. 2, pp. 231–234.

    Article  CAS  Google Scholar 

  26. Itoh, H., Andoh, T., Watanabe, I., Sasaki, T., Kamiya, Y., and Okumura, F., Eur. J. Neurosci., 2000, vol. 12, no. 4, pp. 1253–1262.

    Article  PubMed  CAS  Google Scholar 

  27. Jhamandas, K. and Sutak, M., Br. J. Pharmacol., 1980, vol. 71, no. 1, pp. 201–210.

    PubMed  CAS  Google Scholar 

  28. Olianas, M.C. and Onali, P., J. Neurochem., 2000, vol. 75, no. 1, pp. 233–239.

    Article  PubMed  CAS  Google Scholar 

  29. Miampamba, M., Maillot, C., Million, M., and Tach, Y., Am. J. Physiol. Gastrointest. Liver Physiol., 2002, vol. 282, no. 5, pp. G857–865.

    PubMed  CAS  Google Scholar 

  30. Barnes, J.M., Barnes, N.M., Costall, B., Horovitz, Z.P., Ironside, J.W., Naylor, R.J., and Williams, T.J., J. Cardiovasc. Pharmacol., 1990, vol. 16, no. 2, pp. 234–238.

    Article  PubMed  CAS  Google Scholar 

  31. Du, X.J., Cox, H.S., Dart, A.M., and Esler, M.D., J. Cardiovasc. Pharmacol., 1998, vol. 31, no. 6, pp. 937–944.

    Article  PubMed  CAS  Google Scholar 

  32. Buffelli, M., Pasino, E., and Cangiano, A., Neuroscience, 2001, vol. 104, no. 2, pp. 561–567.

    Article  PubMed  CAS  Google Scholar 

  33. Rossi, S.G., Dickerson, I.M., and Rotundo, R.L., J. Biol. Chem., 2003, vol. 278, no. 27, pp. 24994–25000.

    Article  PubMed  CAS  Google Scholar 

  34. Liu, D.M., Cuevas, J., and Adams, D.J., Eur. J. Neurosci., 2000, vol. 12, no. 7, pp. 2243–2251.

    Article  PubMed  CAS  Google Scholar 

  35. Liu, Y.C., Khawaja, A.M., and Rogers, D.F., Br. J. Pharmacol., 1999, vol. 128, no. 6, pp. 1353–1359.

    Article  PubMed  CAS  Google Scholar 

  36. Rakovska, A., Javitt, D., Raichev, P., Ang, R., Balla, A., Aspromonte, J., and Vizi, S., Brain Res. Bull., 2003, vol. 61, no. 5, pp. 529–536.

    Article  PubMed  CAS  Google Scholar 

  37. Nakata, A., Saito, H., and Nishiyama, N., Brain Res., 1996, vol. 723, nos. 1–2, pp. 135–140.

    Article  PubMed  CAS  Google Scholar 

  38. Schäfer, J., Baumeister, H., Lorenz, A., and Meyerhof, W., Z. Ernahrungswiss, 1998, vol. 37, no. Suppl 1, pp. 75–79.

    PubMed  Google Scholar 

  39. Guillemin, R., Endocrinology, 1976, vol. 99, no. 6, pp. 1653–1654.

    Article  PubMed  CAS  Google Scholar 

  40. Toide, K., Shinoda, M., Takase, M., Iwata, K., and Yoshida, H., Eur. J. Pharmacol., 1993, vol. 233, no. 1, pp. 21–28.

    Article  PubMed  CAS  Google Scholar 

  41. Pirola, C.J., Balda, M.S., Finkielman, S., and Nahmod, V.E., Life Sci., 1984, vol. 34, no. 17, pp. 1643–1649.

    Article  PubMed  CAS  Google Scholar 

  42. Messell, T., Harling, H., Poulsen, S.S., Bersani, M., and Holst, J.J., Regul. Pept., 1992, vol. 38, no. 3, pp. 179–198.

    Article  PubMed  CAS  Google Scholar 

  43. McIntosh, C.H., Dadgar, A., and Kwok, Y.N., Regul. Pept., 1992.

  44. Huang, L.Z. and Winzer-Serhan, U.H., Dev. Neurobiol., 2007, vol. 67, no. 3, pp. 363–377.

    Article  PubMed  CAS  Google Scholar 

  45. Sastry, B.V., Clin. Exp. Pharmacol. Physiol., 1995, vol. 22, no. 4, pp. 288–290.

    Article  PubMed  CAS  Google Scholar 

  46. Alburges, M.E., Hoonakker, A.J., and Hanson, G.R., Eur. J. Pharmacol., 2007, vol. 573, nos. 1–3, pp. 124–132.

    Article  PubMed  CAS  Google Scholar 

  47. Inoue, H., Hashimoto, K., and Ota, Z., Acta. Med. Okayama, 1988, vol. 42, no. 2, pp. 61–67.

    PubMed  CAS  Google Scholar 

  48. Toth, M., Ruskoaho, H., and Lang, R.E., J. Hypertens, vol. 4, no. 6, pp. 538–541.

  49. Speake, P.F., Pirie, S.C., Kibble, J.D., Muneer, A., Taylor, D., Birring, S., and Green, R., Clin. Sci. (Lond), 1993, vol. 85, no. 1, pp. 5–12.

    CAS  Google Scholar 

  50. Louiset, E., Cazin, L., Duval, O., Lamacz, M., Tonon, M.C., and Vaudry, H., Brain Res., 1990, vol. 533, no. 2, pp. 300–308.

    Article  PubMed  CAS  Google Scholar 

  51. Garnier, M., Lamacz, M., Galas, L., Lenglet, S., Tonon, M.C., and Vaudry, H., Endocrinology, 1998, vol. 139, no. 8, pp. 3525–3533.

    Article  PubMed  CAS  Google Scholar 

  52. Katsura, M., Ohkuma, S., Chen, D.T., Tsujimura, A., and Kuriyama, K., Neurosci. Let., 1994, vol. 168, nos. 1–2, pp. 1–4.

    Article  CAS  Google Scholar 

  53. Chan, P., Liu, I.M., Tzeng, T.F., Yang, T.L., and Cheng, J.T., Diabetes Obes. Metab., 2007, vol. 9, no. 1, pp. 39–49.

    Article  PubMed  CAS  Google Scholar 

  54. Genazzani, A.R., Petraglia, F., Facchinetti, F., Golinelli, S., Oltramari, P., Santoro, V., and Volpe, A., J. Clin. Endocrinol. Metab., 1988, vol. 66, no. 2, pp. 279–282.

    Article  PubMed  CAS  Google Scholar 

  55. Dumont, M., Day, R., and Lemaire, S., Life Sci., 1983, vol. 32, no. 3, pp. 287–294.

    Article  PubMed  CAS  Google Scholar 

  56. Ohmori, N., Itoi, K., Tozawa, F., Sakai, Y., Sakai, K., Horiba, N., Demura, H., and Suda, T., Endocrinology, 1995, vol. 136, no. 11, pp. 4858–4863.

    Article  PubMed  CAS  Google Scholar 

  57. Wei, R., Phillips, T.M., and Sternberg, E.M., J. Neuroimmunol., 2002, vol. 131, nos. 1–2, pp. 31–40.

    Article  PubMed  CAS  Google Scholar 

  58. Kubo, T. and Hagiwara, Y., Brain Res., 2005, vol. 1061, no. 1, pp. 36–41.

    Article  PubMed  CAS  Google Scholar 

  59. Hagiwara, Y., Ohi, M., and Kubo, T., Brain Res. Bull., 2005, vol. 67, no. 3, pp. 203–209.

    Article  PubMed  CAS  Google Scholar 

  60. Dussor, G.O., Leong, A.S., Gracia, N.B., Kilo, S., Price, T.J., Hargreaves, K.M., and Flores, C.M., Eur. J. Neurosci., 2003, vol. 18, no. 9, pp. 2515–2526.

    Article  PubMed  Google Scholar 

  61. Bernardini, N., Reeh, P.W., and Sauer, S.K., Neuroreport, 2001, vol. 12, no. 11, pp. 2457–2460.

    Article  PubMed  CAS  Google Scholar 

  62. Henning, R.J. and Sawmiller, D.R., Cardiovasc Res., 2001, vol. 49, no. 1, pp. 27–37.

    Article  PubMed  CAS  Google Scholar 

  63. Pelat, M., Lazartigues, E., Tran, M.A., Gharib, C., Montastruc, J.L., Montastruc, P., and Rascol, O., Eur. J. Pharmacol., 1999, vol. 379, nos. 2–3, pp. 117–124.

    Article  PubMed  CAS  Google Scholar 

  64. Shioda, S., Yada, T., Muroya, S., Takigawa, M., and Nakai, Y., Neurosci Res., 1997, vol. 29, no. 4, pp. 311–318.

    Article  PubMed  CAS  Google Scholar 

  65. Shen, E. and Sun, X., Neurosci. Let., 1995, vol. 195, no. 3, pp. 191–194.

    Article  CAS  Google Scholar 

  66. Hall, T.R., Harvey, S., and Chadwick, A., Gen. Pharmacol., 1985, vol. 16, no. 5, pp. 483–488.

    Article  PubMed  CAS  Google Scholar 

  67. Gürün, M.S., Savci, V., Ulus, I.H., and Kiran, B.K., Neurosci. Let., 1997, vol. 232, no. 2, pp. 79–82.

    Article  Google Scholar 

  68. Pu, H.F., Tan, S.K., Chen, H.L., Jea, J.C., and Liu, T.C., Neuroendocrinology, 1999, vol. 70, no. 5, pp. 324–331.

    Article  PubMed  CAS  Google Scholar 

  69. Meites, J., Clin. Endocrinol. (Oxf), 1977, vol. 6.

  70. Honey, R.N. and Weir, G.C., Endocrinology, 1980, vol. 107, no. 4, pp. 1065–1068.

    Article  PubMed  CAS  Google Scholar 

  71. Robbins, R.J., Sutton, R.E., and Reichlin, S., Brain Res., 1982, vol. 234, no. 2, pp. 377–386.

    Article  PubMed  CAS  Google Scholar 

  72. Koop, H., Behrens, I., Bothe, E., McIntosh, C.H., Pederson, R.A., Arnold, R., and Creutzfeldt, W., Digestion, 1982, vol. 25, no. 2, pp. 96–102.

    Article  PubMed  CAS  Google Scholar 

  73. Krsmanovic, L.Z., Mores, N., Navarro, C.E., Saeed, S.A., Arora, K.K., and Catt, K.J., Endocrinology, 1998, vol. 139, no. 10, pp. 4037–4043.

    Article  PubMed  CAS  Google Scholar 

  74. Mitsuma, T., Hirooka, Y., Nakata, K., and Nogimori, T., Horm. Metab. Res., 1989, vol. 21, no. 1, pp. 8–10.

    Article  PubMed  CAS  Google Scholar 

  75. Lamberton, P., Wu, P., and Jackson, I.M., Endocrinology, 1834–1838, vol. 117, no. 5, P. 1834–1838.

    Article  Google Scholar 

  76. Bazyan, A.S., Orlova, N.V., and Getsova, V.M., Zhurn. VND Im. I.P. Pavlova, 2000, vol. 50, no. 3, pp. 500–508.

    CAS  Google Scholar 

  77. Idova, G.V., Tezisy konf. “Neirokhimiya: Fundamental’nye i prikladnye aspekty” (Proceedings of Conference “Neurochemistry: Fundamental and Applied Aspects), Moscow, 2005, pp. 99.

  78. Gordon, J. and Barnes, N.M., TRENDS in immunology, 2003, vol. 24, no. 8, pp. 438–443.

    Article  PubMed  CAS  Google Scholar 

  79. Daw, N.D., Kakade, S., and Dayan, P., Neural. Networks, 2002, vol. 15, nos. 4–6, pp. 603–616.

    Article  PubMed  Google Scholar 

  80. Ierusalimskii, V.N., Funktsional’naya regulyatsiya i ontogenez mediator-spetsifichnykh sistem neironov bespozvonochnykh:, Doctoral (Biol) Dissertation, Moscow: MGU., 2009.

    Google Scholar 

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  1. Department of Human and Animal Physiology, Biological Faculty, Moscow State University, Moscow, 119899, Russia

    S. V. Koroleva, A. A. Nikolaeva & I. P. Ashmarin

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  2. A. A. Nikolaeva
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Original Russian Text © S.V. Koroleva, A.A. Nikolaeva, I.P. Ashmarin, 2012, published in Neirokhimiya, 2012, Vol. 29, No. 2, pp. 150–161.

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Koroleva, S.V., Nikolaeva, A.A. & Ashmarin, I.P. Types of bioinformatic programs in the continuum of regulatory peptides and non-peptide mediators. Traits of interaction of dopamine and serotonin systems. Neurochem. J. 6, 132–143 (2012). https://doi.org/10.1134/S1819712412020031

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