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GABA and GABA amide metabolism in the brain

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Abstract

We studied glutamine utilization and GABA formation in brain mitochondria from rats that were subjected to aluminum intoxication under conditions of activation or inhibition of phosphate-activated glutaminase (PAG). Phosphate did not influence the activities of rats intoxicated with aluminum. GABA formation from glutamine after inhibition of PAG with 6-diazo-5-oxo-norleucine was similar to the normal level. Intoxication increased glutamine utilization and the formation of GABA and its amide. GABA amide produced more ammonia in rats after intoxication. In the presence of ATP and ammonia sulfate we observed more intense GABA usage after its addition to mitochondria. These data support our hypothesis that GABA formation from glutamine via GABA amide may occur and indicates the higher resistance of the GABA-ergic systems as compared to the glutamatergic systems.

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Authors and Affiliations

  1. Bunyatyan Institute of Biochemistry, National Academy of Sciences, Yerevan, Armenia

    R. G. Kamalyan & A. G. Vardanyan

  2. ul. P. Sevaka 5/1, Yerevan, 0014, Armenia

    R. G. Kamalyan

Authors
  1. R. G. Kamalyan
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  2. A. G. Vardanyan
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Correspondence to R. G. Kamalyan.

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Original Russian Text © R.G. Kamalyan, A.G. Vardanyan, 2012, published in Neirokhimiya, 2012, Vol. 29, No. 2, pp. 118–121.

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Kamalyan, R.G., Vardanyan, A.G. GABA and GABA amide metabolism in the brain. Neurochem. J. 6, 100–103 (2012). https://doi.org/10.1134/S1819712412010035

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  • DOI: https://doi.org/10.1134/S1819712412010035

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