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Involvement of brain intracellular proteolytic systems in the effects of opiates: Caspases

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Abstract

It is well known that opiates, in particular morphine, are involved in a phenomenon of so-called pathological plasticity and can bring about considerable structural-functional changes in the CNS, which is an important mechanism of the formation of dependence. It has been found that realization of pharmacological effects during acute or chronic action of morphine may be related to changes in the activity of receptors, signal cascades mediated by secondary messengers, and shifts in the expression of some genes. Less is known about the relationship between the effects of morphine and functioning of intracellular proteolytic enzymes which are an important system of post-translational modification of proteins. On the basis of our results and data of literature, we hypothesized that a number of structural changes induced by morphine may be mediated by proteolytic enzymes from caspase family.

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Authors and Affiliations

  1. National Research Center of Addiction, Russian Ministry of Health, Moscow, Russia

    A. A. Yakovlev, D. I. Peregud & L. F. Panchenko

  2. Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow, Russia

    A. A. Yakovlev & N. V. Gulyaeva

  3. Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region, Russia

    A. A. Yakovlev

  4. Research Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia

    D. I. Peregud & L. F. Panchenko

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  1. A. A. Yakovlev
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  3. L. F. Panchenko
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  4. N. V. Gulyaeva
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Correspondence to A. A. Yakovlev.

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Original Russian Text © A.A. Yakovlev, D.I. Peregud, L.F. Panchenko, N.V. Gulyaeva, 2011, published in Neirokhimiya, 2011, Vol. 28, No. 4, pp. 274–279.

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Yakovlev, A.A., Peregud, D.I., Panchenko, L.F. et al. Involvement of brain intracellular proteolytic systems in the effects of opiates: Caspases. Neurochem. J. 5, 240–244 (2011). https://doi.org/10.1134/S1819712411040192

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