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The regulatory influence of galarmin on the level and activity of rat tissue metalloproteins after doxorubicin-induced nephro- and cardiotoxicity

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Abstract

Doxorubicin (DR) is a potential antineoplastic drug that is used for therapy of different types of malignant tumors (leukemia, lymphoma, mammary tumor, lung, ovarian, pancreatic tumor etc.). However, the long-term use of DR leads to irreversible cardiomyopathy and nephropathy due to DR-induced formation of free oxygen radicals that disturb the functionality of the mitochondria, membranes, and nuclei of cells. The mechanisms of DR-induced cardiotoxicity and nephrotoxicity associated with changes in the activity of antioxidant metalloproteins (Cu, Zn-SOD, Mn-SOD, and catalase) and prooxidant metalloproteins (acidic isoforms of cytochrome (cyt) b558 and cyt C) in heart and kidney cells are not clear. Here we tried to evaluate these biochemical factors.

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Authors and Affiliations

  1. Buniatian Institute of Biochemistry, National Academy of Sciences, Yerevan, Republic of Armenia

    L. H. Tadevosyan, L. N. Arakelyan, M. A. Simonyan, G. A. Kevorkian & A. A. Galoyan

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  1. L. H. Tadevosyan
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  2. L. N. Arakelyan
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  3. M. A. Simonyan
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  4. G. A. Kevorkian
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  5. A. A. Galoyan
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Corresponding author

Correspondence to L. H. Tadevosyan.

Additional information

Original Russian Text © L.H. Tadevosyan, L.N. Arakelyan, M.A. Simonyan, G.A. Kevorkian, A.A. Galoyan, 2011, published in Neirokhimiya, 2011, Vol. 28, No. 3, pp. 244–248.

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Tadevosyan, L.H., Arakelyan, L.N., Simonyan, M.A. et al. The regulatory influence of galarmin on the level and activity of rat tissue metalloproteins after doxorubicin-induced nephro- and cardiotoxicity. Neurochem. J. 5, 215–219 (2011). https://doi.org/10.1134/S1819712411030123

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  • DOI: https://doi.org/10.1134/S1819712411030123

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