Abstract
We studied the expression of the antioxidant protein thioredoxin-1 in the hippocampus of rat pups that were subjected to hypoxia at prenatal days 14–16, at the 3rd and 14th days after their birth, and at 80–90 days when the pups became mature. In spite of the specific features of certain hippocampal regions and the presence of exceptions related to them, 3 days after birth we observed a general trend to a decrease in thioredoxin-1 expression in rats subjected to hypoxia, as compared to the control animals of the same age. Then, thioredoxin-1 expression was substantially increased on the 14th day of postnatal life. In adult rats, thioredoxin-1 expression decreased again. These changes were very prominent in the CA1 field of the hippocampus. A decrease in the activity of the physiological antioxidant system is an important index of cell-membrane homeostasis, whose impairment under hypoxic conditions can result in the development of neurodegenerative diseases.
Similar content being viewed by others
References
Kassil’, V.G., Otellin, V.A., Khozhai, L.I., and Kostkin, V.B., Ros. Fiziol. Zhurn. im. I.M. Sechenova, 2000, vol. 86, pp. 1418–1425.
Zhuravin, I.A., Tumanova, N.L., and Potapov, D.O., Zh. Evol. Biokh. Fiziol., 2001, vol. 37, pp. 518–520.
Royer, C., Lachuer, J., Crouzoulon, G., Roux, J.-C., Peyronnet, J., Mamet, J., Pequignot, J.-M., and Dalmaz, Y., Brain Res., 2000, vol. 856, pp. 119–128.
Zonberg, G.L., Buka, S.L., and Tsuang, M.T., Amer. J. Psychiatry, 2000, vol. 157, pp. 196–202.
Boksa, P., Brain Res. Rev., 2004, vol. 45, pp. 1–17.
Vataeva, L.A., Kostkin, V.B., Makukhina, G.V., Khozhai, L.I., and Otellin, V.A., Dokl. Akad. Nauk, 2001, vol. 380, pp. 1–3 [Dokl. (Engl. Transl.), vol. 380, pp. ].
Vataeva, L.A., Kostkin, V.B., Makukhina, G.V., Khozhai, L.I., and Otellin, V.A., Zh. Evol. Biokhim. Fiziol., 2004, vol. 40, pp. 350–354.
Florian, C. and Roullet, P., Behavioural Brain Res., 2004, vol. 154, pp. 365–374.
Vataeva, L.A., Tyul’kova, E.I., Khozhai, L.I., Samoilov, M.O., and Otellin, V.A., Zh. Evol. Biokhim. Fiziol., 2005, vol. 41, pp. 532–535.
Tyul’kova, E.I., Semenov, D.G., Vataeva, L.A., and Belyakov, A.V., in “Gipoksicheskoe, ishemicheskoe prekonditsionirovanie mozga.” Sb. trudov Rossiisko-Pol’skogo simpoziuma v ramkakh dnei Pol’skoi nauki v Rossii, (“Hypoxic and Ischemic Brain Preconditioning.” Proc. Russian-Polish Workshop in the Framework of Days of Polish Science in Russia), St. Petersburg, 2008, pp. 97–101.
Tyul’kova, E.I., Vataeva, L.A., and Samoilov, M.O., Zhurn. Evol. Biokh. Fiziol., 2010, vol. 46, no. 5, pp. 406–409.
Holmgren, A., Annu. Rev. Biochem., 1985, vol. 54, pp. 237–271.
Holmgren, A., J. Biol. Chem., 1989, vol. 264, pp. 13963–13966.
Hori, K., Katayama, M., Sato, N., Ishii, K., Waga, S., and Yodoi, J., Brain Res., 1994, vol. 652, pp. 304–310.
Sasada, T., Iwata, S., Sato, N., Kitaoka, Y., Hirota, K., Nakamura, K., Nishiyama, A., Taniguchi, Y., Takabayashi, A., and Yodoi, J., J. Clin. Invest., 1996, vol. 97, pp. 2268–2276.
Takagi, Y., Mitsui, A., Nishiyama, A., Nozaki, K., Sono, H., Gon, Y., Hashimoto, N., and Yodoi, J., Proc. Natl. Acad. Sci. USA, 1999, vol. 96, pp. 4131–4136.
Berggren, M., Gallegos, A., Gasdaska, J.R., Gasdaska, P.Y., Warneke, J., and Powis, G., Anticancer. Res., 1996, vol. 16, pp. 3459–3466.
Tomimoto, H., Akiguchi, I., Wakita, H., Kimura, J., Hori, K., and Yodoi, J., Brain. Res., 1993, vol. 625, pp. 1–8.
Stroev, S.A., Tjulkova, E.I., Gluschenko, T.S., Rybnikova, E.A., Samoilov, M.O., and Pelto-Huikko, M., Neurosci. Lett., 2004, vol. 370, pp. 224–229.
Hattori, I., Takagi, Y., Nozaki, K., Kondo, N., Bai, J., Nakamura, H., Hashimoto, N., and Yodoi, J., Redox Rep., 2002, vol. 7, pp. 256–259.
Takagi, Y., Horikawa, F., Nozaki, K., Sugino, T., Hashimoto, N., and Yodoi, J., Neurosci. Lett., 1998, vol. 251, pp. 25–28.
Takagi, Y., Tokime, T., Nozaki, K., Gon, Y., Kikuchi, H., and Yodoi, J., J. Cereb. Blood. Flow. Metab., 1998, vol. 18, pp. 206–214.
Stroev, S.A., Tyul’kova, E.I., Glushchenko, T.S., Tugoi, I.A., Samoilov, M.O., and Pelto-Huikko, M., Morfologiya, 2008, vol. 133, pp. 20–24.
Chetverikov, D.A., Uspekhi Neirokhimii, (Trends in Neurochemistry) 1974, pp. 73–83.
Rybnikova, E.A., Vataeva, L., Tyulkova, E., Gluschenco, T., Otellin, V., Pelto-Huikko, M., and Samoilov, M.O., Behav. Brain. Res., 2005, vol. 160, no. 1, pp. 107–114.
Paxinos, G. and Watson, C., The Rat Brain in Stereotaxic Coordinates / Second Edition, Sydney, Orlando, San Diego, New York, Austin, London, Montreal, Tokyo, and Toronto: Acad. Press, 1986.
Tugoy, I.A. and Stroev, S.A., Morfologiya, 2006, vol. 129, p. 96.
Golan, H. and Huleihel, M., Dev. Sci., 2006, vol. 9, no. 4, pp. 338–349.
Baines, C.P., Goto, M., and Downey, J.M., J. Mol. Cell. Cardiol., 1997, vol. 29, pp. 207–216.
Kaeffer, N., Richard, V., and Thuillez, C., Circulation, 1997, vol. 96, pp. 2311–2316.
Vanden Hoek, T.L., Becker, L.B., Shao, Z., Li, C., and Schumacker, P.T., J. Biol. Chem., 1998, vol. 273, pp. 18092–18098.
Das, D.K., Maulik, N., Sato, M., and Ray, P.S., Mol. Cell. Biochem., 1999, vol. 196, pp. 59–67.
Rauca, C., Zerbe, R., Jantze, H., and Krug, M., Brain. Res., 2000, vol. 868, pp. 147–149.
Ravati, A., Ahlemeyer, B., Becker, A., and Krieglstein, J., Brain. Res, 2000, vol. 866, pp. 23–32.
Ravati, A., Ahlemeyer, B., Becker, A., Klumpp, S., and Krieglstein, J., J. Neurochem., 2001, vol. 78, pp. 909–919.
Leak, R.K., Liou, A.K., and Zigmond, M.J., J. Neurochem., 2006, vol. 99, pp. 1151–1163.
Sugino, T., Nozaki, K., Takagi, Y., and Hashimoto, N., Neurosci. Lett., 1999, vol. 259, no. 1, pp. 9–12.
Aketa, S., Nakase, H., Kamada, Y., Hiramatsu, K., and Sakaki, T., Exp. Neurol., 2000, vol. 166, pp. 385–391.
Meerson, F.Z., Pozharov, V.P., Minyailenko, T.D., and Golubeva, L.Yu., Byul. Eksp. Biol. Med., 1993, vol. 116, pp. 574–577.
Meerson, F., Pozharov, V., and Minyailenko, T., J. Appl. Physiol., 1994, vol. 76, pp. 1856–1861.
Golubeva, L.Yu., Dvoryantsev, S.N., Khatkevich, A.N., Malyshev, I.Yu., and Meerson, F.Z., Byul. Eksp. Biol. Med., 1995, vol. 120, pp. 481–484.
Author information
Authors and Affiliations
Corresponding author
Additional information
Original Russian Text © S.A. Stroev, E.I. Tyul’kova, L.A. Vataeva, M.O. Samoilov, M.T. Pelto-Huikko, 2011, published in Neirokhimiya, 2011, Vol. 28, No. 3, pp. 226–231.
Rights and permissions
About this article
Cite this article
Stroev, S.A., Tyul’kova, E.I., Vataeva, L.A. et al. Effects of prenatal hypoxia on expression of thioredoxin-1 in the rat hippocampus at different stages of postnatal ontogeny. Neurochem. J. 5, 200–204 (2011). https://doi.org/10.1134/S1819712411030111
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1134/S1819712411030111