Neurochemical Journal

, Volume 4, Issue 1, pp 25–29 | Cite as

The effects of L-DOPA on glutamate dehydrogenase activity in the cerebral neurons of rats with different motor activities

  • A. V. SergutinaEmail author
Experimental Articles


We studied the brains of stress-resistant Wistar rats and stress-prone August rats under normal conditions and after long-term L-DOPA administration. We performed a histochemical study of glutamate dehydrogenase (GDH) activity in layers III and V of the sensorimotor cortex, caudate nucleus, nucleus accumbens, and the CA3 field of the hippocampus. We did not find any differences in the GDH activity in the brain structures of the control Wistar and August rats with high or low levels of locomotion in the “open field” test. The activity of GDH was higher in layer V of the sensorimotor cortex and the caudate nucleus and lower in the hippocampus of August rats with low levels of locomotion as compared to Wistar rats with high locomotor activity. Administration of L-DOPA resulted in an increase in GDH activity in the sensorimotor cortex, caudate nucleus, and nucleus accumbens in Wistar rats with high levels of locomotion in the “open field” test. In Wistar rats with low locomotor activity, L-DOPA activated GDH in the hippocampus and decreased its concentration in the caudate nucleus and nucleus accumbens. In August rats with low levels of locomotion, L-DOPA increased GDH activity in the caudate nucleus and nucleus accumbens and decreased it in layer V of the sensorimotor cortex. The local specificity of GDH activity in the rat brain under normal conditions and during dopaminergic system hyperfunction are discussed.

Key words

glutamate dehydrogenase neuronal cytochemistry stress behavior in the “open field” test 


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© Pleiades Publishing, Ltd. 2010

Authors and Affiliations

  1. 1.Neurology Research CenterRussian Academy of Medical SciencesMoscowRussia
  2. 2.MoscowRussia

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