The effects of L-DOPA on glutamate dehydrogenase activity in the cerebral neurons of rats with different motor activities
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We studied the brains of stress-resistant Wistar rats and stress-prone August rats under normal conditions and after long-term L-DOPA administration. We performed a histochemical study of glutamate dehydrogenase (GDH) activity in layers III and V of the sensorimotor cortex, caudate nucleus, nucleus accumbens, and the CA3 field of the hippocampus. We did not find any differences in the GDH activity in the brain structures of the control Wistar and August rats with high or low levels of locomotion in the “open field” test. The activity of GDH was higher in layer V of the sensorimotor cortex and the caudate nucleus and lower in the hippocampus of August rats with low levels of locomotion as compared to Wistar rats with high locomotor activity. Administration of L-DOPA resulted in an increase in GDH activity in the sensorimotor cortex, caudate nucleus, and nucleus accumbens in Wistar rats with high levels of locomotion in the “open field” test. In Wistar rats with low locomotor activity, L-DOPA activated GDH in the hippocampus and decreased its concentration in the caudate nucleus and nucleus accumbens. In August rats with low levels of locomotion, L-DOPA increased GDH activity in the caudate nucleus and nucleus accumbens and decreased it in layer V of the sensorimotor cortex. The local specificity of GDH activity in the rat brain under normal conditions and during dopaminergic system hyperfunction are discussed.
Key wordsglutamate dehydrogenase neuronal cytochemistry stress behavior in the “open field” test
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- 1.Popova, N.S. and Kachalova, L.M., in Funktsional’noe vzaimodeistvie struktur mozga: printsipy, varianty, modelirovanie (Functional Interaction of Brain Structures: Principles, Variants, and Modeling), Moscow, 2001.Google Scholar
- 4.Mosharova, I.V., Neirokhimiya, 2001, vol. 18, no. 1, pp. 3–18.Google Scholar
- 6.Meldrum, B.S., J. Nutr., 2000, vol. 130, pp. 1007–1015.Google Scholar
- 11.Sudakov, K.V., in Emotsional’nyi stress: teoreticheskie i klinicheskie aspekty (Emotional Stress: Theoretical and Clinical Aspects), Volgograd, 1997.Google Scholar
- 13.Dugan, L.L. and Choi, D.W., in Basic Neurochemistry, New York, 1999, pp. 711–730.Google Scholar
- 17.Simonov, P.V., Motivirovannyi mozg (Motivated Brain), Moscow: Nauka, 1987.Google Scholar
- 18.Simonov, P.V., Zhurn. Vyssh. Nerv. Deyat., 1991, vol. 41, no. 2, pp. 211–220.Google Scholar
- 19.Joel, D. and Weiner, I., in Conceptual Advances in Brain Research: Brain Dynamics and the Striatal Complex, Miller, R. and Wickens, J.R., Eds., Amsterdam: Harwood Acad. Publ., 1999, pp. 209–236.Google Scholar
- 23.Arushanyan, E.B. and Otellin, V.A., in Khvostatoe yadro (The Caudate Nucleus), Leningrad: Nauka, 1976.Google Scholar
- 24.Popova, N.S., Sergutina, A.V., and Gershtein, L.M., in Materialy konferentsii “Plastichnost’ i strukturno-funktsional’naya vzaimosvyaz’ kory i podkorkovykh obrazovanii” (Proc. Conf. “Plasticity and Structural and Functional Interaction of the Cortex and Subcortical Structures), Moscow, 2003, p. 74.Google Scholar