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Neurochemical Journal

, Volume 4, Issue 1, pp 8–13 | Cite as

The α and β estrogen receptors in the human hypothalamus and basal forebrain in Alzheimer’s disease

  • T. A. IshuninaEmail author
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Abstract

Estrogen therapy in early menopause decreases the risk of Alzheimer’s disease. In contrast to the epidemiological and experimental evidence, no positive effects of estrogens on cognition were noted when estrogen therapy was prescribed to Alzheimer’s disease patients. We hypothesize that changes in canonical and alternatively spliced estrogen receptors (ERs) may play a role in these controversial findings. We found that nuclear expression of the ER α increases in the cholinergic structures of the basal forebrain and hypothalamic nuclei involved in cognitive functions and decreases in the hippocampus. Furthermore, certain brain areas in people over 50 years old had ER α splice variants with defective ligandand DNA-binding domains compromised AF1 activation function. The presence of different sets of classical and mutant estrogen receptors in different brain regions may account for the controversial effects of estrogens on cognitive functions in the climacteric period.

Key words

Alzheimer’s disease estrogen receptors splicing variants hypothalamus basal nucleus of Meynert 

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Copyright information

© Pleiades Publishing, Ltd. 2010

Authors and Affiliations

  1. 1.Department of Histology, Embryology, and CytologyKursk State Medical UniversityKurskRussia
  2. 2.KurskRussia

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