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Proteolysis and proteolytic enzymes in structural plasticity of synapses

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Abstract

This review is focused on the role of proteolysis and proteolytic enzymes in long-term plasticity, learning, and memory. The importance of proteolysis in the activation of protein turnover, regulation of actin cytoskeleton motility, endocytosis, exocytosis, and cell adhesion processes is discussed. Experimental data on the activation of proteolytic protein cleavage during an increase in the synthesis and proteolytic cleavage of actin-bound proteins in long-term synaptic plasticity are presented. We discuss the involvement of proteasomes and lysosomes in membrane transport and long-term synaptic plasticity underlying learning and memory.

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  1. Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow, Russia

    I. V. Kudryashova

  2. ul. Butlerova 5a, Moscow, 117485, Russia

    I. V. Kudryashova

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Original Russian Text © I.V. Kudryashova, 2009, published in Neirokhimiya, 2009, Vol. 26, No. 3, pp. 191–201.

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Kudryashova, I.V. Proteolysis and proteolytic enzymes in structural plasticity of synapses. Neurochem. J. 3, 164–172 (2009). https://doi.org/10.1134/S1819712409030027

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