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Neuromediator changes in different rat brain regions after acute morphine intoxication

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Abstract

We investigated the effects of acute morphine intoxication on the functions of the dopaminergic, noradrenergic, and serotonergic systems, and the GABA level in the cerebral cortex, thalamus, and striatum of the rat brain. It was shown that a single morphine administration resulted in changes in neurotransmitter systems, which depended on the morphine dosage and the brain regions examined. Activation of both dopamine and noradrenaline release and catabolism were mostly expressed in the thalamus and striatum. The changes in the GABA level revealed in the cerebral cortex after different acute morphine intoxication were related to the level of behavioral activity of the animals. Changes in the serotonergic system were less pronounced.

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Original Russian Text © V.V. Lelevich, S.V. Lelevich, E.M. Doroshenko, 2009, published in Neirokhimiya, 2009, Vol. 26, No. 1, pp. 56–60.

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Lelevich, V.V., Lelevich, S.V. & Doroshenko, E.M. Neuromediator changes in different rat brain regions after acute morphine intoxication. Neurochem. J. 3, 49–53 (2009). https://doi.org/10.1134/S1819712409010073

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  • DOI: https://doi.org/10.1134/S1819712409010073

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