Abstract
New procedures for the preparation of grafted and branched amphiphilic copolymers based on poly(ethylene glycol) have been suggested. Radical polymerization with TEMPO and sulfuric acid has afforded controlled synthesis of grafted copolymers of methyl methacrylate with poly(ethylene glycol) methacrylate. Radical copolymerization of allyl acetate with poly(ethylene glycol) acrylate in the presence of divinylbenzene has given branched copolymers. It has been shown that these copolymers can form micelles in aqueous medium; cytotoxicity of the copolymers and the ability to suppress the resistance of human cancer cells NCI/ADR-RES have been investigated.
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ACKNOWLEDGMENTS
Authors are grateful to M.V. Bermeshev and E.V. Chernikova for the assistance in GPS analysis of the polymers and to E.M. Budynina for NMR studies of the polymers.
Funding
This study was performed in the scope of the State Task “Modern Problems of Chemistry and Physico-Chemistry of High-Molecular Compounds” (State Budget, no. AAAA-A16-116031050014-6).
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Translated by E. Karpushkin
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Zaremski, M.Y., Melik-Nubarov, N.S., Grozdova, I.D. et al. Amphiphilic Copolymers of Different Structure Based on Poly(ethylene glycol): Synthesis, Physico-Chemical Properties, and Cytotoxicity. Polym. Sci. Ser. C 64, 135–143 (2022). https://doi.org/10.1134/S1811238222700126
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DOI: https://doi.org/10.1134/S1811238222700126