Abstract
Nanochitosan with the size of particles in the range of 20–100 nm is synthesized from chitosan Bombyx mori. It is shown that preparations based on chitosan and nanochitosan are characterized by a well-pronounced antibacterial activity. Nanochitosan is able to substantially enhance the immune response of a living system: it increases the number of cells both in central (thymus, marrow) and peripheral (lymph glands) immune organs of mice.
Similar content being viewed by others
References
C. Yieng-chien, S. U. Ya-ping, C. Chiing-chang, J. I. A. Guang, W. Huey-lan, W. Gaston, and L. Jaunggeng, Acta Pharmacol. Sin. 25 (7), 932 (2004).
K. Nishimura, S. Nishimura, N. Nishi, I. Saiki, S. Tokura, and I. Czuma, Vaccine, No. 2, 93 (1984).
Chitin Enzymology, Ed. by R. A. A. Muzzarelli (Atec Edizioni, Italy, 2001).
K. Ueno, T. Yamaguchi, N. Sakairi, N. Nishi, and S. Tokura, Adv. Chitin Sci., No. 2, 156 (1997).
Y. J. Jeon, P. J. Park, and S. K. Kim, Carbohydr. Res. 44, 71 (2001).
L. Qi, Z. Xu, X. Jiang, C. Hu, and X. Zou, Carbohydr. Res. 339, 2693 (2004).
E. I. Rabea, M. E. Badawy, C. V. Stevens, G. Smagghe, and W. Steurbaut, Biomacromolecules 4 (6), 1457 (2003).
M. N. V. Ravi Kumar, React. Funct. Polym. 46, 1 (2000).
S. H. Lim and S. M. Hudson, Carbohydr. Res. 339, 313 (2004).
S. N. Kulikov, Yu. A. Tyurin, and A. V. Il’ina, Tr. Beloruss. Gos. Univ., No. 4 (1), 95 (2009).
M. Amidi, E. Mastrobattista, W. Jiskoot, and W. Hennink, Adv. Drug Delivery Rev. 62, 59 (2010).
N. Bhattarai, J. Gunn, and M. Zhang, Adv. Drug Delivery Rev. 62 (1), 83 (2010).
M. D. Buschmann, A. Merzouki, M. Lavertu, M. Thibault, M. Jean, and V. Darras, Adv. Drug Delivery Rev. 65, 1234 (2013).
Y. Chiu, Y. Ho, and Y. Chen, J. Controlled Release 146, 152 (2010).
Y. Bei, X. Chen, Y. Liu, J. Xu, W. Wang, Z. Gu, K. Xing, A. Zhu, W. Chen, L. Shi, Q. Wang, X. Zhang, and Q. Zhang, Int. J. Nanomed. 7, 1819 (2012).
S. Sh. Rashidova and R. Yu. Milusheva, Chitin and Chitosan of Bombyx mori. Synthesis, Properties and Application (FAN, Tashkent, 2009) [in Russian].
R. Yu. Milusheva, K. K. Pirniyazov, and S. Sh. Rashidova, Vestn. Tverskogo Gos. Univ., Ser.: Khim., No. 2, 119 (2016).
Y. M. Chen, Y. C. Chung, L. W. Wang, K. T. Chen, and S. Y. Li, J. Environ Sci. Health, Part A: Toxic/Hazard. Subst. Environ. Eng. 37, 1379 (2002).
S. H. Lim and S. M. Hudson, J. Macromol. Sci., Part C: Polym. Rev. 43 (2), 223 (2003).
M. S. Mohy Eldin, E. A. Soliman, A. I. Hashem, and T. M. Tamer, Trends Biomater. Artif. Organs 22 (3), 125 (2008).
N. Liu, X. G. Chen, H. J. Park, C. G. Liu, C. S. Liu, X. H. Meng, and L. J. Yu, Carbohydr. Polym. 64, 60 (2006).
Zh. T. Azimov, B. L. Oksengendler, N. N. Turaeva, and S. Sh. Rashidova, Polym. Sci., Ser. A 55 (2), 98 (2013).
Author information
Authors and Affiliations
Corresponding author
Additional information
Original Russian Text © R.Yu. Milusheva, S.Sh. Rashidova, 2017, published in Vysokomolekulyarnye Soedineniya, Seriya C, 2017, Vol. 59, No. 1, pp. 33–39.
Rights and permissions
About this article
Cite this article
Milusheva, R.Y., Rashidova, S.S. Bioactive properties of nanochitosan Bombyx mori . Polym. Sci. Ser. C 59, 29–34 (2017). https://doi.org/10.1134/S1811238217010088
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1134/S1811238217010088