The main stages and achievements in the investigation of the fate of mRNA in eukaryotic cells, which began half a century ago with the discovery of informosomes by A.S. Spirin, there are discussed. The results of even the most recent studies confirm Spirin’s hypotheses about the structure and function of the informosomes, now called mRNPs. In the bibliography, we present only small part of the published articles in this field. The full list is too large.
This is a preview of subscription content, access via your institution.
Buy single article
Instant access to the full article PDF.
Tax calculation will be finalised during checkout.
Belitsina, N.V., Aitkhozhin, M.A., Gavrilova, L.P., and Spirin, AS., The messenger ribonucleic acids of differentiating animal cells, Biokhimia, 1964, vol. 29, pp. 363–374.
Spirin, A.S., Belitsina, N.V., and Aitkhozhin, M.A., Informational RNA in early embryogenesis, Zh. Obshch. Biol., 1964, vol. 25, pp. 321–338.
Spirin, A.S. and Nemer, M., Messenger RNA in early sea urchin embryos; cytoplasmic particles, Science, 1965, vol. 150, pp. 214–217.
Spirin, A.S., The Second Sir Hans Krebs Lecture, Informosomes, Eur. J. Biochem., 1969, vol. 10, pp. 20–35.
Spirin, A.S., Belitsina, N.V., and Lerman, M.I., Use of formaldehyde fixation for studies of ribonucleoprotein particles by caesium chloride density-gradient centrifugation, J. Mol. Biol., 1965, vol. 14, pp. 611–615.
Neifakh, A.A., Comparative radiation study of the morphogenetic function of nuclei in the development of animals, Zh. Obshch. Biol., 1961, vol. 22, pp. 42–57.
Spirin, A.S., “Masked” forms of mRNA, Curr. Top. Dev. Biol., 1966, vol. 1, pp. 1–38.
Spirin, A.S., Storage of messenger RNA in eukaryotes: envelopment with protein, translational barrier at 5' side, or conformational masking by 3' side?, Mol. Rep. Dev., 1994, vol. 38, pp. 107–117.
Voronina, A.S., The size of RNA within the composition of heavy informosomes from loach embryo cytoplasm, Biochemistry (Moscow), 1985, vol. 50, pp. 1300–1304.
Ovchinnikov, L.P., Voronina, A.S., Stepanov, A.S., Belitsina, N.V., and Spirin, A.S., Informosome-like complexes formed after the addition of RNA to homogenates of animal cells, Mol. Biol., 1968, vol. 2, pp. 601–609.
Stepanov, A.S., Voronina, A.S., Ovchinnikov, L.P., and Spirin, A.S., RNA-binding protein factor of animal cell extracts, FEBS Lett., 1971, vol. 18, pp. 13–18.
Stepanov, A.S. and Voronina, A.S., Formation of stabilized informosome-like particles at physiological temperatures, Dokl. Akad. Nauk SSSR, 1972, vol. 203, pp. 1418–1421.
Elizarov, S.M., Stepanov, A.S., Felgenhauer, P.E., and Chulitskaya, E.V., Involvement of RNA binding proteins in the formation of informosomes in vivo, FEBS Lett., 1978, vol. 93, pp. 219–224.
Kafatos, F.C., Cytoplasmic particles carrying rapidly labeled RNA in developing insect epidermis, Proc. Natl. Acad. Sci. U. S. A., 1968, vol. 59, pp. 1251–1258.
Ajtkhozhin, M.A., Doschanov, Kh.J., and Akhanov, A.U., Informosomes as a stored form of mRNA in wheat embryos, FEBS Lett., 1976, vol. 66, pp. 124–126.
Preobrazhensky, A.A. and Spirin, A.S., Informosomes and their protein components: the present state of knowledge, Progr. Nucl. Acids Res. Mol. Biol., 1978, vol. 21, pp. 1–138.
Belitsina, N.V., Ovchinnikov, L.P., Spirin, A.S., et al., Informosomes of HeLa cells infected with vaccinia virus, Biokhimiya, 1968, vol. 33, pp. 727–735.
Zaslavsky, V.G., Zaides, V.M., Volkova, M.Y., et al., Virus-specific informosome components in the extracts of Newcastle disease virus infected cells, FEBS Lett., 1971, vol. 14, pp. 133–136.
Samarina, O.P., Krichevskaya, A.A., and Georgiev, G.P., Nuclear ribonucleoprotein particles containing messenger ribonucleic acid, Nature, 1966, vol. 25, pp. 1319–1322.
Voronina, A.S., RNA-binding protein factor in the nuclear extract of rat liver cells, FEBS Lett., 1973, vol. 32, pp. 310–312.
Pederson, T., Proteins associated with heterogeneous nuclear RNA in eukaryotic cells, J. Mol. Biol., 1974, vol. 83, pp. 163–183.
Björk, P. and Wieslander, L., Integration of mRNP formation and export, Cell. Mol. Life Sci., 2017, vol. 74, pp. 2875–2897.
Perry, R.P. and Kelly, D.E., Messenger RNA–protein complexes and newly synthesized ribosomal subunits: analysis of free particles and components of polyribosomes, J. Mol. Biol., 1968, vol. 35, pp. 37–59.
Henshaw, E.C., Messenger RNA in rat liver polyribosomes: evidence that it exists as ribonucleoprotein particles, J. Mol. Biol., 1968, vol. 36, pp. 401–411.
Blobel, G., A protein of molecular weight 78.000 bound to the polyadenylate region of eukaryotic messenger RNAs, Proc. Natl. Acad. Sci. U. S. A., 1973, vol. 70, pp. 924–928.
Spirin, A.S., Eukaryotic messenger RNA and informosomes: omnia mea mecum porto, FEBS Lett., 1978, vol. 88, pp. 115–117.
Auerbach, S. and Pederson, T., Phosphorylation of messenger RNA-bound proteins in HeLa cells, Biochem. Biophys. Res. Commun., 1975, vol. 63, pp. 149–156.
Stepanov, A.S., Kandror, K.V., and Elizarov, S.M., Protein kinase activity in RNA-binding proteins of amphibia oocytes, FEBS Lett., 1982, vol. 141, pp. 157–160.
Stepanov, A.S. and Kandror, K.V., The effect of self-phosphorylation of RNA-binding proteins on their RNA-binding activity, Dokl. Akad. Nauk SSSR, 1984, vol. 275, pp. 1227–1230.
Minikh, V.B. and Ovshinnikov, L.P., Role of cytoplasmic mRNP proteins in translation, Biochemistry (Moscow), 1992, vol. 74, pp. 477–483.
Mordovkina, D., Lyabin, D.N., Smolin, E.A., et al., Y-box binding proteins in mRNP assembly, translation, and stability control, Biomolecules, 2020, vol. 10, p. 591.
Voronina, A.S. and Potekhina, E.S., Translational regulation of synthesis of proteins responsible for dorsoventral differentiation of Xenopus laevis embryos, Russ. J. Dev. Biol., 1999, vol. 30, pp. 65–71.
Voronina, A.S. and Pshennikova, E.S., Activity of specific mRNAs in early development of Xenopus and Rana embryos, J. Biol. Sci., 2006, vol. 6, pp. 115–120.
Voronina, A.S. and Pshennikova, E.S., mRNPs: from informosomes to stress granules, Mol. Biol. (Moscow), 2010, vol. 44, no. 4, pp. 520–528.
Quattrone, A. and Dassi, E., The architecture of the human RNA-binding protein regulatory network, Science, 2019, vol. 21, pp. 706–719.
Eichler, C.E., Hakes, A.C., Hull, B., and Gavis, E.R., Compartmentalized oskar degradation in the germ plasm safeguards germline development, Life, 2020, vol. 9, p. 49988.
The authors declare no conflicts of interest. This article does not contain any research involving humans or the use of animals as objects.
Translated by M. Batrukova
About this article
Cite this article
Voronina, A.S., Pshennikova, E.S. To the Academician Alexander Spirin 90th Anniversary from Informosomes to the World of mRNP. Dokl Biochem Biophys 499, 203–206 (2021). https://doi.org/10.1134/S1607672921040177
- RNA-binding proteins
- heavy informosomes
- translation regulation