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Relationship Estimation of Cell Mobility Proteins Level with Processes of Proteolysis and Lymphogenic Metastasis in Breast Cancer


The biological aggressiveness of a tumor is determined by the ability of tumor cells to invade and metastasize which is a consequence of their acquisition of a number of phenotypic characteristics. Remodeling of the actin cytoskeleton occurs during cell migration which is carried out by various groups of actin binding proteins in the regulation of which proteasomes and calpains play an important role. Therefore the study of the relationship of proteins associated with cell motility with the processes of lymphogenous metastasis as well as the assessment of the regulatory role of intracellular proteases in these processes is extremely important for fundamental oncology. This study demonstrates the associations of actin-binding proteins with the activity of proteasomes and calpain, which are specific for tumors and metastases of the mammary gland. We proposed a possible scheme of the relationship of intracellular systems with the actin-binding proteins. The results obtained expand the fundamental understanding of the processes of tumor progression and can also be used in the search for proteins-targets for therapeutic action in molecular targeted cancer therapy.

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Correspondence to E. E. Sereda.

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Statement of compliance with standards of research involving humans as subjects. The work was carried out in accordance with the principles of the Declaration of Helsinki of the World Medical Association “Ethical Principles for Conducting Scientific Medical Research with Human Participation,” as amended in 2000. In addition, informed consent was obtained from each patient included in the study, as well as the permission of the Ethics Committee of the Research Institute of Oncology, TNIMC.

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Sereda, E.E., Kolegova, E.S., Kakurina, G.V. et al. Relationship Estimation of Cell Mobility Proteins Level with Processes of Proteolysis and Lymphogenic Metastasis in Breast Cancer. Dokl Biochem Biophys 499, 211–214 (2021).

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  • breast cancer
  • actin binding proteins
  • proteasomes
  • calpains
  • lymphogenous metastases