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Selection of Laboratory Mice for the Cognitive Task Successful Solution and for the Inability to Solve It


Using the selected mouse strain EX as the founding population (selection for extrapolation ability) three selection generations of mice were obtained, which were selected for successful solution of object permanence test (plus-sub-strain) and for lack of such solution (minus-sub-strain). The successful solution required not only the ability to operate the object permanence rule (by J. Piajet), but the performance of complicated action (executive function) which was significantly higher in plus-substrain, and this is the unique example of successful selection for cognitive trait.

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Correspondence to I. I. Poletaeva.

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Conflict of interest. The authors declare that they have no conflict of interest.

Statement on the welfare of animals. The experimental protocol was accepted by the Bioethical Commission of Moscow State University, session no. 49 of June 18, 2014.


The research was carried out under the state assignment of Ministry of Science and Higher Education of the Russian Federation (theme no. 121032500080-8) and supported by the Russian Foundation for Basic Research (project no. 20-015-00287) and the state program no. ААА-А16-116021660055-1.

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Perepelkina, O.V., Poletaeva, I.I. Selection of Laboratory Mice for the Cognitive Task Successful Solution and for the Inability to Solve It. Dokl Biochem Biophys 499, 207–210 (2021).

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  • elementary logic task
  • selection experiment
  • puzzle-box
  • object permanence rule
  • laboratory mice