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Bis(µ-Tartrato)Di(μ-Hydroxy) Germanate (IV) Triethanolammonium as a Mononuclear Alkaline Phospholipase A2 Inhibitor

  • BIOCHEMISTRY, BIOPHYSICS, AND MOLECULAR BIOLOGY
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Abstract

It was established that the administration of an aqueous solution of bis(µ-tartrato)di(μ-hydroxy) germanate (IV) triethanolammonium to animals daily for 2 months at a dose of the active substance of 10 mg/kg of the animal’s weight leads to inhibition of the total activity of the alkaline phospholipase A2 of mononuclear cells. The results of the study can be used to correct lipid metabolism in the development of disorders in hyperlipidemia. This makes it possible to expand the scope of use of the studied substance and create new pharmaceuticals based on bis(µ-tartrato)di(μ-hydroxy) germanate (IV) triethanolammonium prevent and inhibit the development of hyperlipidemia.

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Authors and Affiliations

  1. Institute of Chemistry and Technology of Organoelement Compounds, Moscow, Russia

    P. A. Storozhenko & M. M. Rasulov

  2. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow, Russia

    I. V. Zhigacheva

  3. Irkutsk State Technical University, Irkutsk, Russia

    V. P. Baryshok

Authors
  1. P. A. Storozhenko
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  2. M. M. Rasulov
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  3. I. V. Zhigacheva
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  4. V. P. Baryshok
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Corresponding author

Correspondence to M. M. Rasulov.

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Conflict of interest. The authors declare that they have no conflict of interest.

Statement on the welfare of animals. The study was performed in accordance with the Rules of Laboratory Practice in the Russian Federation. The rules were approved by order of the Ministry of Health of the Russian Federation dated June 19, 2003 no. 267 (Rules of laboratory practice in the Russian Federation of the Ministry of Health of the Russian Federation, Order no. 267 dated June 19, 2003 http://www.kodeks.ru (April 24, 2010)). Animals were euthanized observing the rules of the European Convention for the Protection of Vertebrate Animals Used for Experimental and Other Scientific Purposes (Strasbourg, 1986).

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Translated by M. Batrukova

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Storozhenko, P.A., Rasulov, M.M., Zhigacheva, I.V. et al. Bis(µ-Tartrato)Di(μ-Hydroxy) Germanate (IV) Triethanolammonium as a Mononuclear Alkaline Phospholipase A2 Inhibitor. Dokl Biochem Biophys 496, 10–13 (2021). https://doi.org/10.1134/S1607672921010105

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  • DOI: https://doi.org/10.1134/S1607672921010105

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