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Depolarization of the Rat Atria in Experimental Simulation of the Holiday Heart Syndrome

  • BIOCHEMISTRY, BIOPHYSICS, AND MOLECULAR BIOLOGY
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Abstract

In the study of the sequence of depolarization of the atrial subepicardium of rats in the short-term alcohol consumption model (the “Holiday heart” syndrome), the localization of the sources of atrial arrhythmias was determined for the first time. The difference in the excitation of the right and left atria was discovered: the right atrium is activated anterogradely from the sinoatrial node, whereas the left atrium is activated retrogradely from the ectopic focus located in the left auricular appendage.

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Authors and Affiliations

  1. Zakusov Research Institute of Pharmacology, Moscow, Russia

    I. M. Roshchevskaya, V. N. Stolyaruk, M. B. Vititnova, I. B. Tsorin & S. A. Kryzhanovsky

  2. Komi Science Center, Ural Branch, Russian Academy of Sciences, Syktyvkar, Russia

    S. L. Smirnova

Authors
  1. S. L. Smirnova
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  2. I. M. Roshchevskaya
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  3. V. N. Stolyaruk
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  4. M. B. Vititnova
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  5. I. B. Tsorin
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  6. S. A. Kryzhanovsky
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Corresponding author

Correspondence to I. M. Roshchevskaya.

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Conflict of interest. The authors have no potential or explicit conflicts of interest related to the manuscript.

Statement on the welfare of animals. The experiments on animals were approved by the Commission on Biomedical Ethics of the Zakusov Research Institute of Pharmacology (protocol no. 4 dated February 28, 2018) in accordance with the rules of the European Convention ETS 123.

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Translated by M. Batrukova

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Smirnova, S.L., Roshchevskaya, I.M., Stolyaruk, V.N. et al. Depolarization of the Rat Atria in Experimental Simulation of the Holiday Heart Syndrome. Dokl Biochem Biophys 495, 304–306 (2020). https://doi.org/10.1134/S1607672920060149

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  • DOI: https://doi.org/10.1134/S1607672920060149

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