Skip to main content
SpringerLink
Log in

Effect of Silicon Dioxide Nanoparticles on Syrian Hamsters Infected by Opisthorchis felineus: 1H MRS Study of the Brain

  • BIOCHEMISTRY, BIOPHYSICS, AND MOLECULAR BIOLOGY
  • Published:
Doklady Biochemistry and Biophysics Aims and scope Submit manuscript

Abstract

In recent years, silicon dioxide nanoparticles have been widely used in medicine and the pharmaceutical industry, however, their effect on the brain has hardly been studied. We assessed the effects of long-term consumption of 5-nm amorphous silicon dioxide nanoparticles (SiO2-NPs) by Syrian hamsters infected with the trematodes Opisthorchis felineus on the hippocampus and frontal cortex. Spectroscopic determination of brain neurometabolites, performed using a horizontal Magnetic Resonance Imaging system at 11.7 Tesla magnetic field, has shown that the ratio of the excitatory neurotransmitters (glutamate + glutamine + aspartate) to the inhibitory ones (GABA + glycine) was higher in the animals infected with O. felineus. However, pre-consumption of the SiO2-NPs solution prevented this imbalance. In addition, the protective effect of SiO2-NPs on the level of myo-inositol and glycine was found. It is concluded that the use of SiO2-NPs can neutralize the negative effects of infectious factors on the brain.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1.
Fig. 2.
Fig. 3.

Similar content being viewed by others

REFERENCES

  1. Ali, A., Suhail, M., Mathew, S., et al., Nanomaterial induced immune responses and cytotoxicity, J. Nanosci. Nanotechnol., 2016, vol. 16, pp. 40–57. https://doi.org/10.1166/jnn.2016.10885

    Article  CAS  PubMed  Google Scholar 

  2. Kusaczuk, M., Kretowski, R., Naumowicz, M., et al., Silica nanoparticle-induced oxidative stress and mitochondrial damage is followed by activation of intrinsic apoptosis pathway in glioblastoma cells, Int. J. Nanomed., 2018, vol. 13, pp. 2279–2294. https://doi.org/10.2147/IJN.S158393

    Article  CAS  Google Scholar 

  3. Guzman-Ruiz, M.A., de La Mora, M.B., Torres, X., et al., Oral silica nanoparticles lack of neurotoxic effects in a Parkinson’s disease model: a possible nanocarrier?, IEEE Trans. Nanobiosci., 2019, vol. 18, pp. 535–541. https://doi.org/10.1109/TNB.2019.2934074

  4. Potapov, V., Muradov, S., Sivashenko, V., et al., Nanosized silicon dioxide: application in medicine and veterinary medicine, Nanoindustriya, 2012, vol. 33, no. 3, pp. 32–36.

    Google Scholar 

  5. Choi, J., Zheng, Q., Katz, H.E., et al., Silica-based nanoparticle uptake and cellular response by primary microglia, Environ. Health Perspect., 2010, vol. 118, pp. 589–595. https://doi.org/10.1289/ehp.0901534

    Article  CAS  PubMed  Google Scholar 

  6. Kalinin, D.V. and Serdobintseva, V.V., A method for producing silica nanoparticles, RF Patent no. 2426 692 S1, Byull. Izobret., 2010, no. 23.

  7. Tereshin, V.A., Kruglova, O.V., Nartov, P.V., et al., The effectiveness of an enterosorbent based on silicon dioxide in the treatment of antibiotic-associated diarrhea, Klin. Infektol. Parazitol., 2019, vol. 8, no. 1, pp. 7–14.

    Google Scholar 

  8. Akhmedov, V.A. and Kritevich, M.A., Chronic opisthorchiasis as multiple organ pathology, Vestn. NGU, Ser.: Biol., Klin. Med., 2009, vol. 7, no. 1, pp. 118–121.

    Google Scholar 

  9. Shevelev, O.B., Tseilikman, V.E., Khotskin, N.V., et al., Anxiety and neurometabolite levels in the hippocampus and amygdala after prolonged exposure to predator-scent stress, Vavilov J. Genet. Breed., 2019, vol. 23, pp. 582–587. https://doi.org/10.18699/VJ19.528

    Article  Google Scholar 

  10. Moshkin, M.P., Akulov, A.E., Petrovski, D.V., et al., Proton magnetic resonance spectroscopy of brain metabolic shifts induced by acute administration of 2-deoxy-D-glucose and lipopolysaccharides, NMR Biomed., 2014, vol. 27, pp. 399–405.

    Article  CAS  Google Scholar 

  11. Dossi, E., Vasile, F., and Rouach, N., Human astrocytes in the diseased brain, Brain Res. Bull., 2018, vol. 136, pp. 139–156. https://doi.org/10.1016/j.brainresbull.2017.02.001

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Li, Y., Mei, L., Qiang, J., et al., Magnetic resonance spectroscopy for evaluating portal-systemic encephalopathy in patients with chronic hepatic schistosomiasis japonicum, PLoS Negl. Trop. Dis., 2016, vol. 12. e0005232. https://doi.org/10.1371/journal.pntd.0005232

    Article  CAS  Google Scholar 

  13. Ublinskii, M.V., Manzhurtsev, A.V., Men’shchikov, P.E., et al., Multimodal studies of the human brain using functional magnetic resonance imaging and magnetic resonance spectroscopy, Ann. Klin. Eksp. Nevrol., 2018, vol. 12, no. 1, pp. 54–60. https://doi.org/10.25692/ACEN.2018.1.8

    Article  Google Scholar 

  14. Aun, A.A.K., Mostafa, A.A., Aboul Fotouh, A.M., et al., Role of magnetic resonance spectroscopy (MRS) in nonlesional temporal lobe epilepsy, Egypt. J. Radiol. Nuclear Med., 2016, vol. 47, pp. 217–231. https://doi.org/10.1016/j.ejrnm.2015.09.008

    Article  Google Scholar 

  15. Pavlov, Ch.S., Damulin, I.V., and Ivashkin, V.T., Hepatic encephalopathy: pathogenesis, clinical picture, diagnosis, and therapy, Ross. Zh. Gastroenterol. Gepatol. Koloproktol., 2016, vol. 26, no. 1, pp. 44–53. https://doi.org/10.22416/1382-4376-2016-26-1-44-53

    Article  Google Scholar 

Download references

Funding

The work was performed within the framework of the state assignment of the Federal Research Center Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences (no. 0324-2019-0041) and the state assignment of the Institute of the Institute of Solid State Chemistry and Mechanochemistry, Siberian Branch, Russian Academy of Sciences (no. 0301-2019-0005). Work with the equipment of the Center for Genetic Resources of Laboratory Animals, Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences was supported by the Ministry of Education and Science of the Russian Federation (unique project identifier RFMEFI62119X0023).

Author information

Authors and Affiliations

  1. Federal Research Center Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences, Novosibirsk, Russia

    M. N. Lvova, O. B. Shevelev, E. L. Zavjalov, V. A. Mordvinov & D. F. Avgustinovich

  2. International Tomography Center, Siberian Branch, Russian Academy of Sciences, Novosibirsk, Russia

    O. B. Shevelev

  3. Sobolev Institute of Geology and Mineralogy, Siberian Branch, Russian Academy of Sciences, Novosibirsk, Russia

    V. V. Serdobintseva & D. V. Kalinin

  4. Budker Institute of Nuclear Physics, Siberian Branch, Russian Academy of Sciences, Novosibirsk, Russia

    D. A. Starostenko &  P. V. Logachev

  5. Novosibirsk State Medical University, Novosibirsk, Russia

    A. L. Krivoshapkin

  6. Institute of Solid State Chemistry and Mechanochemistry, Siberian Branch, Russian Academy of Sciences, Novosibirsk, Russia

    D. F. Avgustinovich

Authors
  1. M. N. Lvova
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. O. B. Shevelev
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. V. V. Serdobintseva
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. D. V. Kalinin
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. D. A. Starostenko
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. E. L. Zavjalov
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. A. L. Krivoshapkin
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. P. V. Logachev
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. V. A. Mordvinov
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. D. F. Avgustinovich
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to M. N. Lvova.

Ethics declarations

Conflict of interest. The authors declare that they have no conflict of interest.

Statement on the welfare of animals. All procedures were carried out in accordance with the directives of the European Communities Council of November 24, 1986 (86/609/EEC) and the conclusion of the Bioethical Commission of the Federal Research Center of ICG SB RAS (protocol No. 39 of September 27, 2017).

Additional information

Translated by M. Batrukova

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Lvova, M.N., Shevelev, O.B., Serdobintseva, V.V. et al. Effect of Silicon Dioxide Nanoparticles on Syrian Hamsters Infected by Opisthorchis felineus: 1H MRS Study of the Brain. Dokl Biochem Biophys 495, 319–324 (2020). https://doi.org/10.1134/S1607672920060095

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S1607672920060095

Keywords:

Search

Navigation