Abstract
The study was carried out on samples of invasive breast carcinoma of no special type from 36 patients aged 48.0 to 62.8 years. The effect of HLDF on nonspecific invasive breast carcinoma was a decrease in the relative content of low-differentiated cells and an increase in the relative content of highly differentiated cells. HLDF did not have a cytotoxic effect leading to the death of low-differentiated cells but promoted promotes the acquisition of a higher degree of differentiation by them. A more pronounced effect of HLDF was observed in more aggressive metastasizing forms of neoplasia, which allows us to consider this differentiation factor as a candidate for use in the differentiation therapy of malignant neoplasms.
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This study was performed under the state assignment of the Ministry of Health of the Russian Federation (no. АААА-А18-118030790008-7).
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Statement of compliance with standards of research involving humans as subjects. All studies were conducted in accordance with the Declaration of Helsinki of the World Medical Association. The study was approved by the Ethics Committee of the Research Institute for Molecular Biology and Biophysics, a division of the Federal Research Center for Basic and Translational Medicine. All persons involved in the study gave their voluntary informed consent to participate in the study.
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Translated by M. Batrukova
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Autenshlyus, A.I., Zhurakovsky, I.P., Davletova, K.I. et al. Influence of HLDF Differentiation Factor on Nonspecific Invasive Breast Carcinoma in vitro. Dokl Biochem Biophys 495, 289–291 (2020). https://doi.org/10.1134/S1607672920060010
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DOI: https://doi.org/10.1134/S1607672920060010