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Neuroprotective and Antioxidant Activity of Arachidonoyl Choline, Its Bis-Quaternized Analogues and Other Acylcholines

  • BIOCHEMISTRY, BIOPHYSICS, AND MOLECULAR BIOLOGY
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Abstract

The antioxidant activity and protective effect in the toxicity model of H2O2 were studied for arachidonic (AA-CHOL), docosahexaenoic (DHA-CHOL), linoleic (Ln-CHOL), and oleic (Ol-CHOL) fatty acids, as well as arachidonoyl dicholine (AA-diCHOL) and O-arachidonoyl bistetramethylaminoisopropanol (ABTAP). AA-CHOL, DHA-CHOL and Ln-CHOL provided a 20% increase in cell survival. AA-CHOL, AA-diCHOL, Ol-CHOL, and ABTAP had a radical-scavenging effect in the ABTS test, approximately equal to the activity of a standard radical scavenger Trolox.

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Funding

The work was supported by the Ministry of Education of Russia, a unique identifier RFMEFI60417X0198 project.

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Authors and Affiliations

  1. Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997, Moscow, Russia

    M. G. Akimov, P. V. Dudina, E. V. Fomina-Ageeva, N. M. Gretskaya, A. A. Bosaya,  V. I. Tsetlin & V. V. Bezuglov

  2. Institute of Physiologically Active Compounds, Russian Academy of Sciences, 142432, Chernogolovka, Moscow oblast, Russia

    E. V. Rudakova & G. F. Makhaeva

  3. Moscow State University, 119991, Moscow, Russia

    G. O. Kagarlitsky & S. A. Eremin

Authors
  1. M. G. Akimov
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  2. P. V. Dudina
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  3. E. V. Fomina-Ageeva
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  4. N. M. Gretskaya
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  5. A. A. Bosaya
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  6. E. V. Rudakova
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  7. G. F. Makhaeva
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  8. G. O. Kagarlitsky
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  9. S. A. Eremin
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  10. V. I. Tsetlin
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  11. V. V. Bezuglov
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Corresponding author

Correspondence to M. G. Akimov.

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The authors declare that they have no conflict of interest. This article does not contain any studies involving animals or human participants performed by any of the authors.

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Translated by M. Batrukova

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Akimov, M.G., Dudina, P.V., Fomina-Ageeva, E.V. et al. Neuroprotective and Antioxidant Activity of Arachidonoyl Choline, Its Bis-Quaternized Analogues and Other Acylcholines. Dokl Biochem Biophys 491, 93–97 (2020). https://doi.org/10.1134/S1607672920020027

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  • DOI: https://doi.org/10.1134/S1607672920020027

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