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Fluorescent DNA Probes: Study of Properties and Methods of Application

  • BIOCHEMISTRY, BIOPHYSICS, AND MOLECULAR BIOLOGY
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Abstract

The results of long-term author’s studies of the optical and complex-forming properties of more than 30 synthetic low-molecular-weight fluorophores specific for DNA are described. These studies made it possible to significantly expand the already existing database of properties of such compounds, clarify the ideas about the patterns linking the mentioned properties of fluorophores with their structure, and formulate recommendations on designing new effective DNA-specific fluorophores. The results of these studies can be used, in particular, in the development of new rapid methods for diagnosing various diseases, biotesting of probiotic and antibiotic properties of various products and wastes, etc.

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ACKNOWLEDGMENTS

This work is dedicated to the memory of Academician of the Russian Academy of Sciences Professor V.I. Shvets, who until the last days of his life took an active part in the studies described here, but unfortunately, due to the sudden death, did not see this work finally completed.

Special thanks are due to Professor V.F. Traven’.

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Authors and Affiliations

  1. All-Russia Research Institute for Food Additives— Branch of V.M. Gorbatov Federal Research Center for Food Systems of RAS, 191014, St. Petersburg, Russia

    V. S. Sibirtsev

  2. St. Petersburg State Technological Institute (Technical University), 190013, St. Petersburg, Russia

    A. V. Garabadgiu &  V. I. Shvets

  3. MIREA—Russian Technological University, 119454, Moscow, Russia

    V. I. Shvets

Authors
  1. V. S. Sibirtsev
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  2. A. V. Garabadgiu
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  3. V. I. Shvets
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Corresponding author

Correspondence to V. S. Sibirtsev.

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The authors declare that they have no conflict of interest. This article does not contain any studies involving animals or human participants performed by any of the authors.

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Translated by M. Batrukova

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Sibirtsev, V.S., Garabadgiu, A.V. & Shvets, V.I. Fluorescent DNA Probes: Study of Properties and Methods of Application. Dokl Biochem Biophys 489, 403–406 (2019). https://doi.org/10.1134/S1607672919060127

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  • DOI: https://doi.org/10.1134/S1607672919060127

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