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Effect of Fabomotizole on Brain Gene Expression in MR Rats in the Open Field Test

  • BIOCHEMISTRY, BIOPHYSICS, AND MOLECULAR BIOLOGY
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Abstract

Selective anxiolytic fabomotizole (Afobazol®) has affinity for the Sigma-1 chaperone receptor site, quinone reductase 2 (NQO2) and MAO-A regulatory sites, and melatonin receptor type 1 (MT1 receptor). The analysis of the effect of fabomotizole on the gene expression profile in the brain of MR (Maudsley Reactive) rats was carried out when modeling emotional stress in the open field test. A change in the expression of 14 genes was found, the results of the functional annotation of which showed that the mechanisms of action of fabomotizole may be associated with the regulation of translation of proteins (Rpl5, Rpl15, Ncl, and Ybx1), synaptic functions (Cplx2, Dlg4, Syngap1, Add1, Rab8b, Klc1, and Chn1), and cellular metabolism (Akr1d1, Bcat1, and Pkm).

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Funding

This work was performed under the State assignment of Zakusov Research Institute of Pharmacology (theme no. 0521-2019-0001).

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Authors and Affiliations

  1. Zakusov Research Institute of Pharmacology, 125315, Moscow, Russia

    Yu.V. Vakhitova, M. V. Voronin, L. F. Zainullina &  S. B. Seredenin

  2. Institute of Biochemistry and Genetics, Ufa Federal Research Center, Russian Academy of Science, 450054, Ufa, Bashkortostan, Russia

    U. Sh. Kuzmina

Authors
  1. Yu.V. Vakhitova
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  2. U. Sh. Kuzmina
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  3. M. V. Voronin
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  4. L. F. Zainullina
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  5. S. B. Seredenin
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Corresponding author

Correspondence to Yu.V. Vakhitova.

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Conflict of interests. The authors declare that they have no conflict of interest.

Statement on the welfare of animals. All applicable international, national, and/or institutional guidelines for the care and use of animals were followed.

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Translated by M. Batrukova

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Vakhitova, Y., Kuzmina, U.S., Voronin, M.V. et al. Effect of Fabomotizole on Brain Gene Expression in MR Rats in the Open Field Test. Dokl Biochem Biophys 488, 313–315 (2019). https://doi.org/10.1134/S1607672919050090

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  • DOI: https://doi.org/10.1134/S1607672919050090

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