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Neuroprotective Action of Amidic Neurolipins in Models of Neurotoxicity on the Culture of Human Neural-Like Cells SH-SY5Y

  • BIOCHEMISTRY, BIOPHYSICS, AND MOLECULAR BIOLOGY
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Abstract

It was established that in neurodegeneration models in the human neuron-like cell line SH-SY5Y, amide derivatives of arachidonic and docosahexaenoic acids were inactive in experiments with MPP+ and CoCl2 but protected from H2O2. The protective activity of neurolipins decreased in the series DHA-DA > AA-SER ≥ AA-GLY > AA-GABA ≥ AA-EA and was manifested starting from a concentration of 0.5 nM.

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ACKNOWLEDGMENTS

This study was supported by the Russian Foundation for Basic Research (project no. 17-00-00105 and 17-00-00109).

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Authors and Affiliations

  1. Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997, Moscow, Russia

    M. G. Akimov, A. M. Ashba, E. V. Fomina-Ageeva, N. M. Gretskaya & V. V. Bezuglov

  2. Institute of Molecular Genetics, Russian Academy of Sciences, 123182, Moscow, Russia

    N. F. Myasoedov

Authors
  1. M. G. Akimov
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  2. A. M. Ashba
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  3. E. V. Fomina-Ageeva
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  4. N. M. Gretskaya
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  5. N. F. Myasoedov
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  6. V. V. Bezuglov
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Correspondence to M. G. Akimov.

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The authors declare that they have no conflict of interest. This article does not contain any studies involving animals or human participants performed by any of the authors.

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Translated by M. Batrukova

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Akimov, M.G., Ashba, A.M., Fomina-Ageeva, E.V. et al. Neuroprotective Action of Amidic Neurolipins in Models of Neurotoxicity on the Culture of Human Neural-Like Cells SH-SY5Y. Dokl Biochem Biophys 485, 141–144 (2019). https://doi.org/10.1134/S1607672919020182

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  • DOI: https://doi.org/10.1134/S1607672919020182

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