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Natural Dicarbonyls Inhibit Peroxidase Activity of Peroxiredoxins

  • BIOCHEMISTRY, BIOPHYSICS, AND MOLECULAR BIOLOGY
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Abstract

It was established that recombinant human peroxiredoxins (Prx1, Prx2, Prx4, and Prx6) inhibit natural dicarbonyls formed during free radical peroxidation of unsaturated lipids (malonic dialdehyde) and oxidative transformations of glucose (glyoxal and methylglyoxal). A possible role of the decrease in the activity of peroxiredoxins under oxidative and carbonyl stress is discussed as an important factor that triggers the molecular mechanisms of vascular wall damage in atherosclerosis and diabetes mellitus.

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Authors and Affiliations

  1. National Medical Research Center of Cardiology, Ministry of Healthcare of the Russian Federation, 121552, Moscow, Russia

    V. Z. Lankin & A. K. Tikhaze

  2. Institute of Cell Biophysics, Russian Academy of Sciences, 142290, Pushchino, Moscow oblast, Russia

    M. G. Sharapov, R. G. Goncharov & V. I. Novoselov

Authors
  1. V. Z. Lankin
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  2. M. G. Sharapov
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  3. R. G. Goncharov
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  4. A. K. Tikhaze
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  5. V. I. Novoselov
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Correspondence to V. Z. Lankin.

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Translated by M. Batrukova

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Lankin, V.Z., Sharapov, M.G., Goncharov, R.G. et al. Natural Dicarbonyls Inhibit Peroxidase Activity of Peroxiredoxins. Dokl Biochem Biophys 485, 132–134 (2019). https://doi.org/10.1134/S1607672919020157

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  • DOI: https://doi.org/10.1134/S1607672919020157

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