Dipeptide Mimetic of the BDNF Loop 4 Possesses Analgetic Activity

Abstract

Previously, we synthesized a dimeric dipeptide mimetic of the brain-derived neurotrophic factor (BDNF) loop 4, GSB-106, which, similarly to BDNF, activated TrkB, PI3K/AKT, and MAPK/ERK. When administered systemically, it exhibited neuroprotective, antidepressant, and antidiabetic activities and stimulated neurogenesis and synaptogenesis. In this study, we established that GSB-106 also exhibits the analgesic activity, typical for BDNF, which was revealed in rats in hot plate and tail flick tests 0.5–48 h after intraperitoneal injection at doses of 0.1 and 1 mg/kg.

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Correspondence to Corresponding Member of the RAS T. A. Gudasheva.

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Translated by M. Batrukova

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Gudasheva, T.A., Konstantinopolsky, M.A., Tarasiuk, A.V. et al. Dipeptide Mimetic of the BDNF Loop 4 Possesses Analgetic Activity. Dokl Biochem Biophys 485, 123–125 (2019). https://doi.org/10.1134/S1607672919020121

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