Abstract
Using Fura-2AM microfluorimetry, we have shown for the first time that sigma-1 receptor agonist, tricyclic antidepressant amitriptyline, significantly inhibits glutoxim- and molixan-induced Ca2+-responses in rat peritoneal macrophages. The results suggest possible involvement of sigma-1 receptors in the signaling cascade induced by glutoxim or molixan and leading to intracellular Ca2+ concentration increase in macrophages.
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References
Rousseaux, C.G. and Greene, S.F., J. Recept. Signal Transduct., 2016, vol. 36, pp. 327–388
Penke, B., Fulop, L., Szucs, M., et al., Curr. Neuropharmacol., 2018, vol. 16, pp. 97–116
Cobos, E.J., Entrena, J.M., Nieto, F.R., et al., Curr. Neuropharmacol., 2008, vol. 6, pp. 344–366
Su, T.-P., Hayashi, T., Maurice, T., et al., Trends Pharmacol. Sci., 2010, vol. 31, pp. 557–566
Kurilova, L.S., Krutetskaya, Z.I., Lebedev, O.E., et al., Tsitologiia, 2008, vol. 50, no. 5, pp. 452–461
Villard, V., Meunier, J., Chevallier, N., et al., J. Pharmacol. Sci., 2011, vol. 115, pp. 279–292
Gillman, P.K., Brit. J. Pharmacol., 2007, vol. 151, pp. 737–748
Milenina, L.S., Krutetskaya, Z.I., Naumova, A.A., et al., Tsitologiia, 2015, vol. 57, no. 7, pp. 518–525
Grynkiewicz, G., Poenie, M., and Tsien, R.Y., J. Biol. Chem., 1985, vol. 260, pp. 3440–3450
Xie, Q., Zhang, Y., Zhai, C., et al., J. Biol. Chem., 2002, vol. 277, pp. 16559–16566
Harper, J.L. and Daly, J.W., Drug Dev. Res., 1999, vol. 47, pp. 107–117
Brailou, G.C., Deliu, E., Console-Bram, L.M., et al., Biochem. J., 2016, vol. 473, pp. 1–5
Srivats, S., Balasuriya, D., Pasche, M., et al., J. Cell Biol., 2016, vol. 213, pp. 65–79
Hamplova-Peichlova, J., Krusek, J., Paclt, I., et al., Physiol. Res., 2002, vol. 51, pp. 317–321
Zahradnik, I., Minarovic, I., and Zahradnikova, Z., J. Pharmacol. Exp. Ther., 2008, vol. 324, pp. 977–984
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Original Russian Text © Z.I. Krutetskaya, L.S. Milenina, A.A. Naumova, S.N. Butov, V.G. Antonov, A.D. Nozdrachev, 2018, published in Doklady Akademii Nauk, 2018, Vol. 481, No. 5.
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Krutetskaya, Z.I., Milenina, L.S., Naumova, A.A. et al. Amitriptyline Attenuates Ca2+ Responses Induced by Glutoxim and Molixan in Macrophages. Dokl Biochem Biophys 481, 222–224 (2018). https://doi.org/10.1134/S1607672918040117
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DOI: https://doi.org/10.1134/S1607672918040117