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Doklady Biochemistry and Biophysics

, Volume 478, Issue 1, pp 55–57 | Cite as

Study of Biodistribution of the Modular Nanotransporters after Systemic Administration in Murine Cloudman S91 Melanoma Model

  • Y. V. Khramtsov
  • A. V. Ulasov
  • A. A. Rosenkranz
  • G. P. Georgiev
  • A. S. Sobolev
Biochemistry, Biophysics, and Molecular Biology

Abstract

The distribution of modular nanotransporters (MNTs) that are used to deliver drugs into melanoma cell nuclei after their intravenous administration into mice with Cloudman S91 melanoma was studied. The modification of MNTs with polyethylene glycol (PEG) of different length and their administration during the treatment with docetaxel, nitroglycerin, and excess of nonspecific MNTs leads to an improved accumulation of MNTs in the tummor. Among the variants studied, the MNT with attached PEG with Mr 40 kDa exhibited the best properties.

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References

  1. 1.
    Sobolev, A.S., BioEssays, 2008, vol. 30, pp. 278–287.CrossRefPubMedGoogle Scholar
  2. 2.
    Slastnikova, T.A., Rosenkranz, A.A., Gulak, P.V., et al., Int. J. Nanomed., 2012, vol. 7, pp. 467–482.Google Scholar
  3. 3.
    Slastnikova, T.A., Rosenkranz, A.A., Lupanova, T.N., et al., Dokl. Biochem. Biophys., 2012, vol. 446, no. 3, pp. 235–237.CrossRefPubMedPubMedCentralGoogle Scholar
  4. 4.
    Slastnikova, T.A., Rosenkranz, A.A., Khramtsov, Y.V., et al., Drug Des. Devel. Ther., 2017, vol. 11, pp. 1315–1334.CrossRefPubMedPubMedCentralGoogle Scholar
  5. 5.
    Slastnikova, T.A., Rosenkranz, A.A., Morozova, N.B., et al., Int. J. Nanomed., 2017, vol. 12, pp. 395–410.CrossRefGoogle Scholar
  6. 6.
    Aloia, T.A. and Fahy, B.N., Expert Rev. Anticancer Ther., 2010, vol. 10, pp. 521–527.CrossRefPubMedGoogle Scholar
  7. 7.
    Durymanov, M.O., Yarutkin, A.V., Bagrov, D.V., et al., J. Control. Release, 2016, vol. 232, pp. 20–28.CrossRefPubMedGoogle Scholar
  8. 8.
    Rosenkranz, A.A., Slastnikova, T.A., Khramtsov, Yu.V., et al., Dokl. Biochem. Biophys., 2017, vol. 473, pp. 85–87.CrossRefPubMedGoogle Scholar
  9. 9.
    Siegrist, W., Solca, F., Stutz, S., et al., Cancer Res., 1989, vol. 49, pp. 6352–6358.PubMedGoogle Scholar
  10. 10.
    Thurber, G.M. and Wittrup, K.D., J. Theor. Biol., vol. 314, pp. 57–68.Google Scholar
  11. 11.
    Pfister, D. and Morbidelli, M., J. Control. Release, 2014, vol. 180, pp. 134–149.CrossRefPubMedGoogle Scholar
  12. 12.
    Xue, H.Y., Tran, N., and Wong, H.L., Eur. J. Pharm. Biopharm., 2016, vol. 108, pp. 68–75.CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Pleiades Publishing, Ltd. 2018

Authors and Affiliations

  • Y. V. Khramtsov
    • 1
  • A. V. Ulasov
    • 1
  • A. A. Rosenkranz
    • 1
    • 2
  • G. P. Georgiev
    • 1
  • A. S. Sobolev
    • 1
    • 2
  1. 1.Institute of Gene BiologyRussian Academy of SciencesMoscowRussia
  2. 2.Faculty of BiologyMoscow State UniversityMoscowRussia

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