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Doklady Biochemistry and Biophysics

, Volume 478, Issue 1, pp 41–43 | Cite as

Phospholipase A2 Inhibitors Modulate the Effect of Trifluoperazine on the Intracellular Ca2+ Concentration in Macrophages

  • Z. I. Krutetskaya
  • L. S. Milenina
  • A. A. Naumova
  • S. N. Butov
  • V. G. Antonov
  • A. D. Nozdrachev
Biochemistry, Biophysics, and Molecular Biology
  • 15 Downloads

Abstract

Using Fura-2AM microfluorimetry, it was shown for the first time that phospholipase A2 inhibitors 4-bromophenacyl bromide and glucocorticosteroids prednisolone and dexamethasone attenuate Ca2+ responses induced by neuroleptic trifluoperazine in macrophages. The results suggest the involvement of phospholipase A2 and arachidonic acid metabolism cascade in the effect of trifluoperazine on intracellular Ca2+ concentration in macrophages.

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References

  1. 1.
    Dilsaver, S.C., Amer. Fam. Phys., 1993, vol. 47, pp. 199–204.Google Scholar
  2. 2.
    Sudeshna, G. and Parimal, K., Eur. J. Pharmacol., 2010, vol. 648, pp. 6–14.CrossRefPubMedGoogle Scholar
  3. 3.
    Hadjimitova, V., Bakalova, R., Traykov, T., et al., Cell Biol. Toxicol., 2003, vol. 19, pp. 3–12.CrossRefPubMedGoogle Scholar
  4. 4.
    Milenina, L.S., Krutetskaya, Z.I., Naumova, A.A., et al., in Sb. Retseptory i vnutrikletochnaya signalizatsiya (Receptors and Intracellular Signaling: Collected Papers), 2017, pp. 188–192.Google Scholar
  5. 5.
    Oruch, R., Lund, A., Pryme, I.F., et al., J. Chem. Biol., 2010, vol. 3, pp. 67–88.CrossRefPubMedPubMedCentralGoogle Scholar
  6. 6.
    Jaszczyszyn, A., Gasiorowski, K., Swiatek, P., et al., Pharmacol. Rep., 2012, vol. 64, pp. 16–23.CrossRefPubMedGoogle Scholar
  7. 7.
    Walenga, R.W., Opas, E.E., and Feinstein, M.B., J. Biol. Chem., 1981, vol. 256, pp. 12523–12528.PubMedGoogle Scholar
  8. 8.
    Irvine, R.F., Biochem. J., 1982, vol. 204, pp. 3–16.CrossRefPubMedPubMedCentralGoogle Scholar
  9. 9.
    Gewert, K. and Sundler, R., Biochem. J., 1995, vol. 307, pp. 499–504.CrossRefPubMedPubMedCentralGoogle Scholar
  10. 10.
    Milenina, L.S., Krutetskaya, Z.I., Naumova, A.A., et al., Tsitologiya, 2015, vol. 57, no.7. S. 518–525.Google Scholar
  11. 11.
    Grynkiewicz, G., Poenie, M., and Tsien, R.Y., J. Biol. Chem., 1985, vol. 260, pp. 3440–3450.PubMedGoogle Scholar
  12. 12.
    Xie, Q., Zhang, Y., Zhai, C., et al., J. Biol. Chem., 2002, vol. 277, pp. 16559–16566.CrossRefPubMedGoogle Scholar

Copyright information

© Pleiades Publishing, Ltd. 2018

Authors and Affiliations

  • Z. I. Krutetskaya
    • 1
  • L. S. Milenina
    • 1
  • A. A. Naumova
    • 1
  • S. N. Butov
    • 1
  • V. G. Antonov
    • 1
  • A. D. Nozdrachev
    • 1
  1. 1.St. Petersburg State UniversitySt. PetersburgRussia

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