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Doklady Biochemistry and Biophysics

, Volume 478, Issue 1, pp 8–13 | Cite as

Action of Iron Nitrosyl Complexes, NO Donors, on the Activity of Sarcoplasmic Reticulum Ca2+-ATPase and Cyclic Guanosine Monophosphate Phosphodiesterase

  • L. V. Tat’yanenko
  • N. A. Sanina
  • O. V. Dobrokhotova
  • A. I. Kotelnikov
  • N. S. Goryachev
  • I. I. Pihteleva
  • G. I. Kozub
  • T. A. Kondrateva
Biochemistry, Biophysics, and Molecular Biology
  • 25 Downloads

Abstract

The effect of iron nitrosyl complexes, NO donors, of a general formula [Fe2(L)2(NO)4] with functional sulfur-containing ligands (L-3-nitro-phenol-2-yl, 4-nitro-phenol-2-yl, or 1-methyl-tetrazol-5-yl) on the activity of sarcoplasmic reticulum Ca2+-ATPase and cyclic guanosine monophosphate phosphodiesterase (cGMP PDE) was studied. The test complexes uncoupled the hydrolytic and transport functions of Ca2+- ATPase, thus disturbing the balance of Ca2+ ions in cells, which may affect the formation of thrombi and adhesion of metastatic cells to the endothelium of capillaries. They also inhibited the activity of cGMP PDE, thereby contributing to the accumulation of the second messenger cGMP. The studied iron nitrosyl complexes can be considered as potential drugs.

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Copyright information

© Pleiades Publishing, Ltd. 2018

Authors and Affiliations

  • L. V. Tat’yanenko
    • 1
  • N. A. Sanina
    • 1
  • O. V. Dobrokhotova
    • 1
  • A. I. Kotelnikov
    • 1
  • N. S. Goryachev
    • 1
  • I. I. Pihteleva
    • 1
  • G. I. Kozub
    • 1
  • T. A. Kondrateva
    • 1
  1. 1.Institute of Energy Problems of Chemical Physics, Chernogolovka BranchRussian Academy of SciencesChernogolovka, Moscow oblastRussia

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