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Synthesis and Membrane Transport of Serotonin in the Developing Ovarian Follicle of Mouse

  • Biochemistry, Biophysics, and Molecular Biology
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Abstract

Using RT-PCR, we showed the presence of Tph1 mRNA in follicular cells and Tph2 mRNA in oocytes isolated from primary multilayer ovarian follicles of mouse and the absence of Ddc expression, which indicates that serotonin cannot be synthesized in a developing ovarian follicle. The membrane serotonin transporter Sert is expressed in follicular cells and oocytes. Experiments on the cultivation of follicles in vitro confirmed the absence of serotonin synthesis from 5-hydroxytryptophan and the presence of membrane transport activity in the oocyte.

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Authors and Affiliations

  1. Koltzov Institute of Developmental Biology, Russian Academy of Sciences, ul. Vavilova 26, Moscow, 119334, Russia

    D. A. Nikishin & Y. B. Shmukler

  2. Moscow State University, Moscow, 119992, Russia

    D. A. Nikishin & N. M. Alyoshina

Authors
  1. D. A. Nikishin
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  2. N. M. Alyoshina
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  3. Y. B. Shmukler
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Correspondence to D. A. Nikishin.

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Original Russian Text © D.A. Nikishin, N.M. Alyoshina, Y.B. Shmukler, 2018, published in Doklady Akademii Nauk, 2018, Vol. 478, No. 1, pp. 103–106.

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Nikishin, D.A., Alyoshina, N.M. & Shmukler, Y.B. Synthesis and Membrane Transport of Serotonin in the Developing Ovarian Follicle of Mouse. Dokl Biochem Biophys 478, 4–7 (2018). https://doi.org/10.1134/S1607672918010027

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  • DOI: https://doi.org/10.1134/S1607672918010027

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