Abstract
We studied the genetic diversity of the Yakut population using exome sequencing. We performed comparative analysis of the Yakut population and the populations that are included in the “1000 Genomes” project and we identified the alleles specific to the Yakut population. We showed, that the Yakuts population is a separate cluster between Europeans and East Asians.
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Fedorova, S.A., Geneticheskie portrety narodov Respubliki Sakha, Yakutiya: analiz linii mitokhondrial’noi DNK i Y-khromosomy (Genetic Portraits of People of the Republic of Sakha, Yakutia: Analysis of Lines of Mitochondrial DNA and Y-Chromosome), YaNTs SORAN, 2008.
Fedorova, S.A., Reidla, M., Metspalu, E., Metspalu, M., Rootsi, S., Tambets, K., Trofimova, N., Zhadanov, S.I, Hooshiar Kashani, B., Olivieri, A., Voevoda, M.I., Osipova, L.P., Platonov, F.A., Tom-sky, M.I., Khusnutdinova, E.K., Torroni, A., and Villems, R., Autosomal and uniparental portraits of the native populations of Sakha (Yakutia): implications for the peopling of Northeast Eurasia, BMC Evol. Biol., 2013, vol. 13, no. 1, p. 127.
Sudmant, P.H., Mallick, S., Nelson, B.J., Hormozdiari, F., Krumm, N., Huddleston, J., Coe, B.P., Baker, C., Nordenfelt, S., Bamshad, M., Jorde, L.B., Posukh, O.L., Sahakyan, H., Watkins, W.S., Yepiskoposyan, L., Abdullah, M.S., Bravi, C.M., Capelli, C., Hervig, T., Wee, J.T.S., Tyler-Smith, C., van Driem, G., Romero, I.G., Jha, A.R., Karachanak-Yankova, S., Toncheva, D., Comas, D., Henn, B., Kivisild, T., Ruiz-Linares, A., Sajantila, A., Metspalu, E., Parik, J., Villems, R., Starikovskaya, E.B., Ayodo, G., Beall, C.M., Di Rienzo, A., Hammer, M., Khusainova, R., Khusnutdinova, E., Klitz, W., Winkler, C., Labuda, D., Metspalu, M., Tishkoff, S.A., Dryomov, S., Sukernik, R., Patterson, N., Reich, D., and Eichler. E.E., Global diversity, population stratification, and selection of human copy number variation, Science, 2015, vol. 349, no. 6253.
Langmead, B. and Salzberg, S.L, Fast gapped-read alignment with Bowtie 2, Nat. Methods, 2012, vol. 9, no. 4, pp. 357–359.
Schmutz, J., Wheeler, J., Grimwood, J., Dickson, M., Yang, J., Caoile, C., Bajorek, E., Black, S., Chan, Y.M., Denys, M., Escobar, J., Flowers, D., Fotopulos, D., Garcia, C., Gomez, M., Gonzales, E., Haydu, L., Lopez, F., Ramirez, L., Retterer, J., Rodriguez, A., Rogers, S., Salazar, A., Tsai, M., and Myers, R.M, Quality assessment of the human genome sequence, Nature, 2004, vol. 429, no. 6990, pp. 365–368.
DePristo, M.A., Banks, E., Poplin, R., Garimella, K.V., Maguire, J.R., Hartl, C., Philippakis, A.A., del Angel, G., Rivas, M.A., Hanna, M., McKenna, A., Fennell, T.J., Kernytsky, A.M., Sivachenko, A.Y., Cibulskis, K., Gabriel, S.B., Altshuler, D., and Daly, M.J., A framework for variation discovery and genotyping using nextgeneration DNA sequencing data, Nat. Genet., Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved, 2011, vol. 43, no. 5, pp. 491–498.
Manichaikul, A., Mychaleckyj, J.C., Rich, S.S., Daly, K., Sale, M., and Chen. W.M, Robust relationship inference in genome-wide association studies, Bioinformatics, 2010, vol. 26, no. 22, pp. 2867–2873.
McQuillan, R., Leutenegger, A.-L., Abdel-Rahman, R., Franklin, C.S., Pericic, M., Barac-Lauc, L., Smolej-Narancic, N., Janicijevic, B., Polasek, O., Tenesa, A., Macleod, A.K., Farrington, S.M., Ru-dan, P., Hayward, C., Vitart, V., Rudan, I., Wild, S.H., Dunlop, M.G., Wright, A.F., Campbell, H., and Wilson, J.F, Runs of homozygosity in European populations, Am. J. Hum. Genet. Elsevier, 2008, vol. 83, no. 3, pp. 359–372.
Stoltzfus, A. and Norris, R.W, On the causes of evolutionary transition: transversion bias, Mol. Biol. Evol., Oxford University Press, 2016, vol. 33, no. 3, pp. 595–602.
The dating of the first phase of ethnogenesis of the Yakuts and the beginning of the colonization of the territory of Yakutia [Electronic resource]. http://new.chronologia.org/volume10/turin_dat_jakuty. php#52 (accessed: 10.05.2015).
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Original Russian Text © A.S. Zlobin, S.Sh. Sharapov, V.P. Guryev, M.R. Bevova, Y.A. Tsepilov, T.M. Sivtseva, U.A. Boyarskih, E.A. Sokolova, Y.S. Aulchenko, M.L. Filipenko, V.L. Osakovsky, 2017, published in Doklady Akademii Nauk, 2017, Vol. 474, No. 4, pp. 505–509.
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Zlobin, A.S., Sharapov, S.S., Guryev, V.P. et al. Population specific analysis of Yakut exomes. Dokl Biochem Biophys 474, 213–216 (2017). https://doi.org/10.1134/S1607672917030188
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DOI: https://doi.org/10.1134/S1607672917030188