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Arginine derivatives of dicarboxylic acids from the parotid gland secretions of common toad Bufo bufo—New agonists of ionotropic γ-aminobutyric acid receptors

  • Biochemistry, Biophysics, and Molecular Biology
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Abstract

Compounds activating γ-aminobutyric acid type A receptor were isolated from the toad Bufo bufo venom as a result of chromatographic separation. Analysis of the structure of these compounds by mass spectrometry and nuclear magnetic resonance showed that they are arginine derivatives of dicarboxylic acids and represent suberylarginine, pimeloylarginine, and adipoylarginine.

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Authors and Affiliations

  1. Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, Moscow, 117997, Russia

    D. S. Lebedev, I. A. Ivanov, E. V. Kryukova, V. G. Starkov, V. I. Tsetlin & Yu. N. Utkin

  2. The National University of Science and Technology MISiS, Moscow, Russia

    Yu. N. Utkin

Authors
  1. D. S. Lebedev
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  2. I. A. Ivanov
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  3. E. V. Kryukova
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  4. V. G. Starkov
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  5. V. I. Tsetlin
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  6. Yu. N. Utkin
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Corresponding author

Correspondence to D. S. Lebedev.

Additional information

Original Russian Text © D.S. Lebedev, I.A. Ivanov, E.V. Kryukova, V.G. Starkov, V.I. Tsetlin, Yu.N. Utkin, 2017, published in Doklady Akademii Nauk, 2017, Vol. 474, No. 2, pp. 243–247.

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Lebedev, D.S., Ivanov, I.A., Kryukova, E.V. et al. Arginine derivatives of dicarboxylic acids from the parotid gland secretions of common toad Bufo bufo—New agonists of ionotropic γ-aminobutyric acid receptors. Dokl Biochem Biophys 474, 178–182 (2017). https://doi.org/10.1134/S1607672917030127

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  • DOI: https://doi.org/10.1134/S1607672917030127

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