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Kinetics of DNA elongation

  • Biochemistry, Biophysics, and Molecular Biology
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Abstract

A mathematical model of the DNA elongation stage is proposed, and a formula for calculating the characteristic time of doubling a DNA strand consisting of a large numbers of nucleotides was derived. It is shown that, when the number of nucleotides is greater than 50, it is fair to use a linear dependence of the elongation time on the number of nucleotides. Calculations of the DNA elongation time for a number of organisms are given.

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Authors and Affiliations

  1. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow, 117977, Russia

    V. I. Bykov, A. V. Lukovenkov & S. D. Varfolomeev

Authors
  1. V. I. Bykov
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  2. A. V. Lukovenkov
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  3. S. D. Varfolomeev
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Correspondence to A. V. Lukovenkov.

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Original Russian Text © V.I. Bykov, A.V. Lukovenkov, S.D. Varfolomeev, 2017, published in Doklady Akademii Nauk, 2017, Vol. 474, No. 3, pp. 370–373.

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Bykov, V.I., Lukovenkov, A.V. & Varfolomeev, S.D. Kinetics of DNA elongation. Dokl Biochem Biophys 474, 189–192 (2017). https://doi.org/10.1134/S1607672917030061

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  • DOI: https://doi.org/10.1134/S1607672917030061

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