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The effect of chlorpromazine on intracellular Ca2+ concentration in macrophages

  • Biochemistry, Biophysics, and Molecular Biology
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Abstract

Using Fura-2AM microfluorimetry, it was shown for the first time that neuroleptic chlorpromazine causes intracellular Ca2+ concentration increase in macrophages due to Ca2+ mobilization from intracellular Ca2+ stores and subsequent Ca2+ entry from the external medium. Chlorpromazine-induced Ca2+ entry is inhibited by La3+ and 2-aminoethoxydiphenyl borate and is associated with Ca2+ store depletion.

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Authors and Affiliations

  1. St. Petersburg State University, St. Petersburg, 199034, Russia

    Z. I. Krutetskaya, L. S. Milenina, A. A. Naumova, S. N. Butov, V. G. Antonov & A. D. Nozdrachev

Authors
  1. Z. I. Krutetskaya
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  2. L. S. Milenina
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  3. A. A. Naumova
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  4. S. N. Butov
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  5. V. G. Antonov
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  6. A. D. Nozdrachev
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Corresponding author

Correspondence to Z. I. Krutetskaya.

Additional information

Original Russian Text © Z.I. Krutetskaya, L.S. Milenina, A.A. Naumova, S.N. Butov, V.G. Antonov, A.D. Nozdrachev, 2017, published in Doklady Akademii Nauk, 2017, Vol. 474, No. 1, pp. 116–118.

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Krutetskaya, Z.I., Milenina, L.S., Naumova, A.A. et al. The effect of chlorpromazine on intracellular Ca2+ concentration in macrophages. Dokl Biochem Biophys 474, 162–164 (2017). https://doi.org/10.1134/S1607672917030036

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  • DOI: https://doi.org/10.1134/S1607672917030036

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