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5-Lipoxygenase inhibitor zileuton inhibits Ca2+-responses induced by glutoxim and molixan in macrophages

  • Biochemistry, Biophysics, and Molecular Biology
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Abstract

Using Fura-2AM microfluorimetry, we have shown for the first time that 5-lipoxygenase specific inhibitor antiasthmatic agent zileuton significantly inhibits Ca2+-responses induced by glutoxim and molixan in macrophages. The results support 5-lipoxygenase involvement in the effect of glutoxim and molixan on intracellular Ca2+ concentration in macrophages and indicate the inadvisability of a combined use of drugs glutoxim and molixan and antiasthmatic agent zileuton.

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Authors and Affiliations

  1. St. Petersburg State University, Universitetskaya nab. 7/9, St. Petersburg, 199034, Russia

    Z. I. Krutetskaya, L. S. Milenina, A. A. Naumova, V. G. Antonov & A. D. Nozdrachev

Authors
  1. Z. I. Krutetskaya
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  2. L. S. Milenina
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  3. A. A. Naumova
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  4. V. G. Antonov
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  5. A. D. Nozdrachev
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Corresponding author

Correspondence to Z. I. Krutetskaya.

Additional information

Original Russian Text © Z.I. Krutetskaya, L.S. Milenina, A.A. Naumova, V.G. Antonov, A.D. Nozdrachev, 2016, published in Doklady Akademii Nauk, 2016, Vol. 469, No. 5, pp. 635–637.

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Krutetskaya, Z.I., Milenina, L.S., Naumova, A.A. et al. 5-Lipoxygenase inhibitor zileuton inhibits Ca2+-responses induced by glutoxim and molixan in macrophages. Dokl Biochem Biophys 469, 302–304 (2016). https://doi.org/10.1134/S1607672916040177

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  • DOI: https://doi.org/10.1134/S1607672916040177

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