Doklady Biochemistry and Biophysics

, Volume 469, Issue 1, pp 273–276 | Cite as

Neuropeptide cycloprolylglycine increases the levels of brain-derived neurotrophic factor in neuronal cells

  • T. A. Gudasheva
  • K. N. Koliasnikova
  • T. A. Antipova
  • S. B. Seredenin
Biochemistry, Biophysics, and Molecular Biology


It was shown for the first time that the endogenous cyclic dipeptide cycloprolylglycine (CPG) at concentrations of 10–7 and 10–3 M and piracetam at a concentration of 10–3 M increased the content of brainderived neurotrophic factor (BDNF) in the culture of neuronal cells in normal state and under conditions of glutamate and 6-oxydopamine neurotoxicity. This may indicate the possible involvement of BDNF in the mechanism of action of neuropeptide CPG and piracetam.


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Copyright information

© Pleiades Publishing, Ltd. 2016

Authors and Affiliations

  • T. A. Gudasheva
    • 1
  • K. N. Koliasnikova
    • 1
  • T. A. Antipova
    • 1
  • S. B. Seredenin
    • 1
  1. 1.Zakusov Research Institute of PharmacologyRussian Academy of Medical SciencesMoscowRussia

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