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Antitumor effect of arabinogalactan and platinum complex

Doklady Biochemistry and Biophysics volume 467, pages 92–94 (2016)Cite this article

Abstract

The article presents the results of investigation of antitumor properties of platinum–arabinogalactan complex. We showed the ability of the complex to inhibit the growth of Ehrlich ascites tumor cells. It is found that the distribution of the platinum–arabinogalactan complex is not specific only for tumor cells in mice. The complex was found in all tissues and organs examined (ascites cells, embryonic cells, kidney, and liver). The mechanism of action of the arabinogalactan–platinum complex may be similar to cisplatin as the complex is able to accumulate in tumor cells.

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References

  1. Groman, E.V., Enriquez, P.M., Jung, Chu., and Josephson, L., Arabinogalactan for hepatic drug delivery, Bioconjugate Chem., 1994, no. 5, pp. 547–556.

    Article  CAS  Google Scholar 

  2. Ueno, T., Twase, H., Yamaguchi, Y., and Uemura, T., Pharmacokinetics and biodisposition of fluorescentlabeled arabinogalactan in rats, Intern. J. Pharm., 2000, vol. 201, no. 1, pp. 59–69.

    Article  Google Scholar 

  3. Grieshop, C.M., Flickinger, E.A., and Fahey, G.C., Oral administration of arabinogalactan affects immune status and fecal microbial populations in dogs, J. Nutr., 2002, vol. 132, no. 3, pp. 478–482.

    CAS  PubMed  Google Scholar 

  4. Arikhodzhaev, A.O., G Galactans and galactan-containing polysaccharides of higher plants, Khim. Prir. Soedin., 2000, no. 3, pp. 547–556.

    Google Scholar 

  5. Go, R. and Adjeri, A., Review of the comparative pharmacology and clinical activity of cisplatin and carboplatin, J. Clin. Oncol., 1999, vol. 17, pp. 409–415.

    CAS  PubMed  Google Scholar 

  6. Smyshlyaeva, E.A and Kolpakova, N.A., The ability of cisplatin to be absorbed by tumors and tissues, Sovrem. Naukoemk. Tekhnol., 2004, no. 3, pp. 90–91.

    Google Scholar 

  7. Starkov, A.K. and Kogai, B.E., A procedure for obtaining Pt-derived arabinogalactan, RFPatent No. 2406508, Byull. Izobret., no. 35, 2010.

    Google Scholar 

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Authors and Affiliations

  1. Institute of Chemistry and Chemical Technology, Siberian Branch, Russian Academy of Sciences, Krasnoyarsk, Russia

    A. K. Starkov & S. A. Kuznetsova

  2. Voino-Yasenetskii State Medical University, Ministry of Health of the Russian Federation, ul. Partizana Zheleznyaka 1, Krasnoyarsk, Krasnoyarsk krai, 660022, Russia

    T. N. Zamay, A. A. Savchenko, E. V. Ingevatkin & O. S. Kolovskaya

  3. Siberian Federal University, Svobodnyi pr. 79, Krasnoyarsk, 660041, Russia

    T. N. Zamay, A. A. Savchenko, N. M. Titova, N. A. Luzan, P. P. Silkin & S. A. Kuznetsova

  4. Kirenskii Institute of Physics, Siberian Branch, Russian Academy of Sciences, Akademgorodok, Krasnoyarsk, 660036, Russia

    T. N. Zamay & O. S. Kolovskaya

Authors
  1. A. K. Starkov
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  2. T. N. Zamay
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  3. A. A. Savchenko
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  4. E. V. Ingevatkin
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  5. N. M. Titova
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  6. O. S. Kolovskaya
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  7. N. A. Luzan
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  8. P. P. Silkin
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  9. S. A. Kuznetsova
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Corresponding author

Correspondence to T. N. Zamay.

Additional information

Original Russian Text © A.K. Starkov, T.N. Zamay, A.A. Savchenko, E.V. Ingevatkin, N.M. Titova, O.S. Kolovskaya, N.A. Luzan, P.P. Silkin, S.A. Kuznetsova, 2016, published in Doklady Akademii Nauk, 2016, Vol. 467, No. 1, pp. 112–114.

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Starkov, A.K., Zamay, T.N., Savchenko, A.A. et al. Antitumor effect of arabinogalactan and platinum complex. Dokl Biochem Biophys 467, 92–94 (2016). https://doi.org/10.1134/S1607672916020046

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  • DOI: https://doi.org/10.1134/S1607672916020046

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