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Content of deuterium in biological fluids and organs: Influence of deuterium depleted water on D/H gradient and the process of adaptation

Abstract

It is found that consumption of deuterium depleted water reduces not only the content of deuterium in biological fluids but also more than 2 times reduces the D/H gradient value along the line: mixed saliva > blood plasma. The experimental data showed that a physiological solution prepared on deuterium depleted water during induced apoptosis activates the DNA repair system, significantly reducing the number of single-stranded DNA breaks, which, in general, indicates an increase in the efficiency of defensive systems of the cell.

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References

  1. West, J.B., Bowen, G.J., Cerling, T.E., and Ehleringer, J.R., Trends Ecol. Evol., 2006, vol. 21, no. 7, pp. 408–414.

    PubMed  Article  Google Scholar 

  2. Bowen, G.J., Science, 2011, vol. 332, pp. 430–431.

    PubMed  Article  Google Scholar 

  3. Konovalov, A.I. and Ryzhkina, I.S., Izv. Ross. Akad. Nauk, Ser. Khim., 2014, no. 1, pp. 1–14.

    Google Scholar 

  4. O’Grady, S.P., Valenzuela, L.O., and Remien, C.H., Amer. J. Primatol., 2012, vol. 74, no. 7, pp. 651–660.

    Article  Google Scholar 

  5. Podlesak, D.W., Bowen, G.J., O’Grady, S., et al., Isotopes Environ. Health Stud., 2012, vol. 48, pp. 259–279.

    PubMed  CAS  Article  Google Scholar 

  6. O’Brien, D.M. and Wooler, M.J., Rapid Commun. Mass Spectrom., 2007, vol. 21, pp. 2422–2430.

    PubMed  Article  Google Scholar 

  7. Gyongyi, Z., Budan, F., Szabo, I., et al., Nutrition Cancer, 2013, vol. 65, no. 2, pp. 240–246.

    PubMed  CAS  PubMed Central  Article  Google Scholar 

  8. Nikitin, D.I., Oranskaya, M.N., and Lobyshev, V.I., Biofizika, 2003, vol. 48, no. 4, pp. 678–682.

    PubMed  CAS  Google Scholar 

  9. Gil’miyarova, F.N., Radomskaya, V.M., Gergel’, N.I., et al., Analiticheskie podkhody k izucheniyu pokazatelei metabolizma v rotovoi zhidkosti. Uchebnoe posobie (Analytical Approaches to the Study of Metabolic Indices in Oral Fluid A Tutorial), Moscow: Izvestiya, 2006.

    Google Scholar 

  10. Baryshev, M.G., Basov, A.A., Bolotin, S.N., et al., Bull. Rus. Acad. Sci. Phys., 2012, vol. 76, no. 12, pp. 1349–1352.

    CAS  Article  Google Scholar 

  11. Kreuzer-Martin, H.W., Ehleringer, J.R., and Hegg, E.L., Proc. Nat. Acad. Sci. United States, 2005, vol. 102, no. 48, pp. 17337–17341.

    CAS  Article  Google Scholar 

  12. Dzhimak, S.S., Barishev, M.G., Basov, A.A., and Timakov, A.A., Biophysics, 2014, vol. 59, no. 4, pp. 614–619.

    CAS  Article  Google Scholar 

  13. Chereshnev, V.A. and Gusev, E.Yu., Med. Immunol., 2001, vol. 3, no. 3, pp. 361–368.

    Google Scholar 

  14. Buchachenko, A.L. and Kuznetsov, D.A., Vestn. Ross. Akad. Nauk, 2008, vol. 78, no. 7, pp. 579–583.

    CAS  Google Scholar 

  15. Bruce, S.J., Rey, F., Beguin, A., et al., Anal. Biochem., 2014, vol. 455, pp. 20–25.

    PubMed  CAS  Article  Google Scholar 

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Correspondence to S. S. Dzhimak.

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Original Russian Text © S.S. Dzhimak, A.A. Basov, M.G. Baryshev, 2015, published in Doklady Akademii Nauk, 2015, Vol. 465, No. 2, pp. 245–248.

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Dzhimak, S.S., Basov, A.A. & Baryshev, M.G. Content of deuterium in biological fluids and organs: Influence of deuterium depleted water on D/H gradient and the process of adaptation. Dokl Biochem Biophys 465, 370–373 (2015). https://doi.org/10.1134/S1607672915060071

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  • DOI: https://doi.org/10.1134/S1607672915060071

Keywords

  • Deuterium
  • Blood Plasma
  • Biological Fluid
  • Body Weight Gain
  • DOKLADY Biochemistry