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Computer-aided modeling of activity and selectivity of quinazolinones as noncompetitive NMDA receptor antagonists

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References

  1. Schapira, A.H.V., Bezard, E., Brotchie, J., et al., Nat. Rev. Drug Disc., 2006, vol. 5, pp. 845–854.

    Article  CAS  Google Scholar 

  2. Zefirov, N.S., Palyulin, V.A., and Radchenko, E.V., Dokl. Chem., 1997, vol. 352, nos. 4–6, pp. 23–26 [Dokl. Akad. Nauk, 1997, vol. 352, no. 5, pp. 630–633].

    Google Scholar 

  3. Palyulin, V.A., Radchenko, E.V., and Zefirov, N.S., J. Chem. Inf. Comp. Sci., 2000, vol. 40, no. 3, pp. 659–667.

    Article  CAS  Google Scholar 

  4. Radchenko, E.V., Palyulin, V.A., and Zefirov, N.S., in Chemoinformatics Approaches to Virtual Screening, Cambridge: RSC, 2008, pp. 150–181.

    Book  Google Scholar 

  5. Mosley, C.A., Acker, T.M., Hansen, K.B., et al., J. Med. Chem., 2010, vol. 53, no. 15, pp. 5476–5490.

    Article  PubMed  CAS  Google Scholar 

  6. Radchenko, E.V., Palyulin, V.A., and Zefirov, N.S., XVI Eur. Symp. on Quantitative Structure-Activity Relationships and Molecular Modelling, Italy, 2006, p. 207.

  7. Sobolevsky, A.I., Rosconi, M.P., and Gouaux, E., Nature, 2009, vol. 462, pp. 745–756.

    Article  PubMed  CAS  Google Scholar 

  8. Šali, A. and Blundell, T.L., J. Mol. Biol., 1993, vol. 234, no. 3, pp. 779–815.

    Article  PubMed  Google Scholar 

  9. Larkin, M.A., Blackshields, G., Brown, N.P., et al., Bioinformatics, 2007, vol. 23, no. 21, pp. 2947–2948.

    Article  PubMed  CAS  Google Scholar 

  10. Kuo, A., Gulbis, J.M., Antcliff, J.F., et al., Science, 2003, vol. 300, no. 5627, pp. 1922–1926.

    Article  PubMed  CAS  Google Scholar 

  11. Karakas, E., Simorowski, N., and Furukawa, H., Nature, 2011, vol. 475, pp. 249–253.

    Article  PubMed  CAS  Google Scholar 

  12. Furukawa, H. and Gouaux, E., EMBO J., 2003, vol. 22, no. 12, pp. 2873–2885.

    Article  PubMed  CAS  Google Scholar 

  13. Laskowski, R.A., MacArthur, M.W., Moss, D.S., and Thornton, J.M., J. Appl. Crystallogr., 1993, vol. 26, no. 2, pp. 283–291.

    Article  CAS  Google Scholar 

  14. Morris, G.M., Huey, R., Lindstrom, W., et al., J. Comput. Chem., 2009, vol. 30, no. 16, pp. 2785–2791.

    Article  PubMed  CAS  Google Scholar 

  15. Balannik, V., Menniti, F.S., Paternain, A.V., et al., Neuron, 2005, vol. 48, no. 2, pp. 279–288.

    Article  PubMed  CAS  Google Scholar 

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Original Russian Text © E.V. Radchenko, D.S. Karlov, V.A. Palyulin, N.S. Zefirov, V.M. Pentkovski, 2012, published in Doklady Akademii Nauk, 2012, Vol. 443, No. 5, pp. 637–641.

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Radchenko, E.V., Karlov, D.S., Palyulin, V.A. et al. Computer-aided modeling of activity and selectivity of quinazolinones as noncompetitive NMDA receptor antagonists. Dokl Biochem Biophys 443, 118–122 (2012). https://doi.org/10.1134/S1607672912020159

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  • DOI: https://doi.org/10.1134/S1607672912020159

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