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Copolymers of Sodium Styrene Sulfonate and 2-Deoxy-2-methacrylamido-D-glucose with Antiviral Activity

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Abstract

The radical copolymerization of sodium styrene sulfonate with vinyl saccharide 2-deoxy-2-methacrylamido-D-glucose in water is studied. For sodium styrene sulfonate and 2-deoxy-2-methacrylamido-D-glucose the reactivity ratios are found to be r1 = 1.58 ± 0.05 and r2 = 0.18 ± 0.01, respectively. Water-soluble copolymers of varying compositions and molecular weights demonstrating high antiviral activity are synthesized.

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ACKNOWLEDGMENTS

We are grateful to V.V. Glebenkova for her participation in the experimental work.

Funding

This work was carried out within State Assignment: chemical part, the project registration number 122012100171-8, and biological experiments, the project registration number of RD in the Unified State RD Accounting Information System 121051900142-0 “Genetic and antigenic variability of modern strains of respiratory syncytial viruses (RSV) circulating on the territory of the Russian Federation.”

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Authors and Affiliations

  1. Institute of Macromolecular Compounds, Russian Academy of Sciences, 199004, St. Petersburg, Russia

    E. F. Panarin & O. N. Zhuravskaya

  2. Smorodintsev Influenza Research Institute, 197376, St. Petersburg, Russia

    A. A. Shtro

Authors
  1. E. F. Panarin
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  2. O. N. Zhuravskaya
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  3. A. A. Shtro
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Correspondence to E. F. Panarin.

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The authors declare that they have no conflicts of interest.

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Translated by T. Soboleva

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Panarin, E.F., Zhuravskaya, O.N. & Shtro, A.A. Copolymers of Sodium Styrene Sulfonate and 2-Deoxy-2-methacrylamido-D-glucose with Antiviral Activity. Polym. Sci. Ser. B 65, 129–132 (2023). https://doi.org/10.1134/S1560090423700793

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  • DOI: https://doi.org/10.1134/S1560090423700793

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