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Hyperbranched polylysines: Mechanism of formation

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Abstract

To gain insight into the mechanism treating formation of hyperbranched polylysines through the polymerization of N ɛ-carbobenzoxylysine N-carboxyanhydride under conditions of the reductive removal of a N ɛ-carbobenzoxy group, hyperbranched polylysine has been synthesized with the use of trifluoroacetic acid as a terminator in the polymerization of N-carboxyanhydride. The structure of the polymers is studied by capillary electrophoresis, low-pressure gel-permeation chromatography, circular dichroism, and enzymatic hydrolysis with trypsin. At the first stage of synthesis, a low-molecular-mass strongly branched core of the polymer is formed. At the second stage, polylysine chains are grafted via one point onto amino groups of N-terminal lysine moieties of the low-molecular-mass core through their carboxyl ends.

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Authors and Affiliations

  1. Institute of Macromolecular Compounds, Russian Academy of Sciences, Bol’shoi pr. 31, St. Petersburg, 199004, Russia

    G. P. Vlasov, I. I. Tarasenko, G. A. Pankova & I. E. Il’ina

  2. Institute of Cytology, Russian Academy of Sciences, Tikhoretskii pr. 4, St. Petersburg, 194064, Russia

    V. I. Vorob’ev

Authors
  1. G. P. Vlasov
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  2. I. I. Tarasenko
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  3. G. A. Pankova
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  4. I. E. Il’ina
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  5. V. I. Vorob’ev
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Corresponding author

Correspondence to G. P. Vlasov.

Additional information

Original Russian Text © G.P. Vlasov, I.I. Tarasenko, G.A. Pankova, I.E. Il’ina, V.I. Vorob’ev, 2009, published in Vysokomolekulyarnye Soedineniya, Ser. B, 2009, Vol. 51, No. 8, pp. 1559–1566.

This work was supported by the Russian Foundation for Basic Research, project nos. 04-03-33032 and 07-03-00290.

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Vlasov, G.P., Tarasenko, I.I., Pankova, G.A. et al. Hyperbranched polylysines: Mechanism of formation. Polym. Sci. Ser. B 51, 296–302 (2009). https://doi.org/10.1134/S1560090409070136

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  • DOI: https://doi.org/10.1134/S1560090409070136

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