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Comparison of Dose–Response Curves between EBT-XD and EBT3 Radiochromic Films at High Dose Range (2000–4500 cGy) for a 175 MeV Proton Beam

  • RADIOBIOLOGY, ECOLOGY AND NUCLEAR MEDICINE
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Physics of Particles and Nuclei Letters Aims and scope Submit manuscript

Abstract

To characterise and compare the response of EBT-XD and EBT3 radiochromic films at high doses (up to 4500 cGy) for a 175 MeV energy proton beam. EBT-XD and EBT3 film dosimeters were irradiated by a proton beam with 175 MeV. In order to establish dose response curves, each film piece was exposed to radiation doses 50–4500 cGy. The films were irradiated to doses of 200, 1000, 2000, and 4000 cGy and non-irradiated to determine the lateral response artifact (LRA) for varied lateral positions. The influence of film orientations (0°, 90°, and 45°) on the scanner bed was examined. Net optical density (netOD) for the films was measured at 24, 48, 72 h and 1-week post-irradiation. Digital images were created using an EPSON 11 000 XL scanner. To analyse and present our results we use: ImageJ (v. 2.0) and OriginPro 2015. The red mode netOD was lower in the EBT-XD film, with a netOD for 4500 cGy of 0.610 (EBT-XD) versus 0.893 (EBT3). The EBT-XD film presented a better lateral response than the EBT3. For films irradiated at 4000 cGy placed near the scanner edge, the differences from the central position were 17 and 16.7% (EBT3) and 10.8 and 9.1% (EBT-XD). The EBT3 film presented a satisfactory dose-response for doses <2000 cGy and would be suitable for dosimetry in standard and hypofractionated proton therapy. The EBT-XD film, however, performs better for ultra-hypofractionated proton therapy (>2000 cGy). The new EBT-XD could be a suitable dosimeter for emerging techniques, such as FLASH and Arc proton therapy.

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REFERENCES

  1. K. Soliman, M. Adili, and A. Alrushoud, “Radiation dose verification of an X-ray based blood irradiator using EBT3 radiochromic films calibrated using Gamma Knife machine,” Rep. Pract. Oncol. Radiother. 24, 369–374 (2019).

    Article  Google Scholar 

  2. S. Devic, “Radiochromic film dosimetry: Past, present and future,” Phys. Med. 27, 122–134 (2011).

    Article  Google Scholar 

  3. C. G. Soares, “Radiochromic film dosimetry,” Rad. Meas. 41, S100–S116 (2007).

    Article  Google Scholar 

  4. J. A. Mirza, H. Park, S.-Y. Park, and S.-J. Ye, “Use of radiochromic film as a high-spatial resolution dosimeter by Raman spectroscopy,” Med. Phys. 43, 4520 (2016).

    Article  Google Scholar 

  5. J. F. Dempsey, D. A. Low, S. Mutic, et al., “Validation of precision radiochromic film dosimetry system for quantitative two-dimensional imagining of acute exposure dose distributions,” Med. Phys. 27, 2462–2475 (2000).

    Article  Google Scholar 

  6. L. Zhao and I. J. Das, “Gafchromic film dosimetry in proton beams,” Phys. Med. Biol. 55, N291–N230 (2010).

    Google Scholar 

  7. B. D. Lynch, J. Kozelka, M. K. Ranade, J. K. Li, W. E. Simon, and J. F. Dempsey, “Important considerations for radiochromic film dosimetry with flatbed CCD scanners and EBT GAFCHROMIC® film,” Med. Phys. 33, 4551–4556 (2006).

    Article  Google Scholar 

  8. T. A. Brown, K. R. Hogstrom, D. Alvarez, K. L. Matthews II, K. Ham, and J. P. Dugas, “Dose-response curve of EBT, EBT2, and EBT3 radiochromic films to synchrotron-produced monochromatic X-ray beams,” Med. Phys. 39, 7412–7417 (2012).

    Article  Google Scholar 

  9. B. Arjomandy, R. Tailor, A. Amand, et al., “Energy dependence and dose response of Gafchromic EBT2 film over a wide range of photon, electron, and proton beam energies,” Med. Phys. 37, 1942–1947 (2010).

    Article  Google Scholar 

  10. D. Kirby, S. Green, H. Palmans, R. Hugtenburg, C. Wojnecki, and D. Parker, “LET dependence of GafChromic films and an ion chamber in low-energy proton dosimetry,” Phys. Med. Biol. 55, 417–433 (2010).

    Article  Google Scholar 

  11. M. Fuss, E. Sturtewagen, C. de Wagter, and D. Georg, “Dosimetric characterization of GafChromic EBT film and its implication on film dosimetry quality assurance,” Phys. Med. Biol. 52, 4211–4225 (2007).

    Article  Google Scholar 

  12. M. Martisikova and O. Jakel, “Dosimetric properties of Gafchromic® EBT films in monoenergetic medical ion beams,” Phys. Med. Biol. 55 (10), N281–290 (2010).

    Article  ADS  Google Scholar 

  13. S. Devic, J. Seuntjens, E. Sham, and E. B. Podgorsak, “Precise radiochromic film dosimetry using a flat-bed document scanner,” Med. Phys. 32, 2245–2253 (2005).

    Article  Google Scholar 

  14. D. Lewis, A. Micke, X. Yu, and M. Chan, “An efficient protocol for radiochromic film dosimetry and measurement in a single scan,” Med. Phys. 39, 6339–6350 (2012).

    Article  Google Scholar 

  15. J. F. Calvo-Ortega, M. Pozo, S. Moragues, and J. Casals, “Fast protocol for radiochromic film dosimetry using a cloud computing web application,” Phys. Med. 39, 1–8 (2017).

    Article  Google Scholar 

  16. S. J. van Hoff, P. V. Granton, G. Landry, M. Podesta, and F. Verhaegen, “Evaluation of a novel triple channel radiochromic film analysis procedure using EBT2,” Phys. Med. Biol. 57, 4353–4368 (2012).

    Article  Google Scholar 

  17. A. L. Palmer, D. Bradley, and A. Nisbet, “Evaluation and implementation of triple-channel radiochromic film dosimetry in brachytherapy,” J. Appl. Clin. Med. Phys. 15, 280–296 (2014).

    Article  Google Scholar 

  18. A. Micke, D. F. Lewis, and X. Yu, “Multichanel film dosimetry with nonuniformity correction,” Med. Phys. 38, 2523–2534 (2011).

    Article  Google Scholar 

  19. R. W. Gao, K. R. Olivier, et al., “Single-fraction stereotactic body radiation therapy versus conventionally fractionated radiation therapy for the treatment of prostate cancer bone metastases,” Adv. Radiat. Oncol. 4, 314–322 (2019).

    Article  Google Scholar 

  20. M. E. Daly, J. R. Perks, and A. M. Chen, “Patterns-of-care for thoracic stereotactic body radiotherapy among practicing radiation oncologists in the United States,” J. Thorac. Oncol. 8, 202–207 (2013).

    Article  Google Scholar 

  21. H. Miura, S. Ozawa, et al., “Gafchromic EBT-XD film: Dosimetry characterization in high-dose, volumetric-modulated arc therapy,” J. Appl. Clin. Med. Phys. 17, 312–322 (2016).

    Article  Google Scholar 

  22. E. L. Covington, J. D. Snyder, X. Wu, R. A. Cardan, and R. A. Popple, “Assessing the feasibility of single target radiosurgery quality assurance with portal dosimetry,” J. Appl. Clin. Med. Phys. 20, 135–140 (2019).

    Article  Google Scholar 

  23. A. Palmer, A. Dimitriadis, A. Nisbet, and C. H. Clark, “Evaluation of Gafchromic EBT-XD film, with comparision to EBT3 film, and application in high dose radiotherapy verification,” Phys. Med. Biol. 60, 8741–8752 (2015).

    Article  Google Scholar 

  24. D. F. Lewis and M. F. Chan, “On Gafchromic EBT-XD film and the lateral response artifact,” Med. Phys. 43, 643–649 (2016).

    Article  Google Scholar 

  25. M. P. Grams, J. M. Gustafson, K. M. Long, and L. E. Fong de los Santos, “Initial characterization of the new EBT-XD Gafchromic film,” Med. Phys. 42 5782–5786 (2015).

    Article  Google Scholar 

  26. A. A. Schoenfeld, S. Wieker, D. Harder, and B. Poppe, “The origin of the flatbed scanner artifacts in radiochromic film dosimetry-key experiments and theoretical descriptions,” Phys. Med. Biol. 61, 7704–7724 (2016).

    Article  Google Scholar 

  27. A. A. Schoenfeld, S. Wieker, D. Harder, and B. Poppe, “Changes of the optical characteristics of radiochromic films in the transition from EBT3 to EBT-XD films,” Phys. Med. Biol. 61, 5426–5442 (2016).

    Article  Google Scholar 

  28. J. A. Mirza, R. H. Millares, G. I. Kim, S. Y. Park, J. Lee, and S. J. Ye, “Characterization of radiochromic films as a micrometer-resolution dosimeter by confocal Raman spectroscopy,” Med. Phys. 46, 5238–5248 (2019).

    Article  Google Scholar 

  29. S. Vallieres, C. Bienveneue, et al., “Low-energy proton calibration and energy-dependence linearization of EBT-XD radiochromic films,” Rev. Sci. Instrum. 90, 083301 (2019).

    Article  ADS  Google Scholar 

  30. S. Khachonkham, R. Dreindl, et al., “Characteristic of EBT-XD and EBT3 radiochromic film dosimetry for photon and proton beams,” Phys. Med. Biol. 63, 065007 (2018).

    Article  Google Scholar 

  31. Ch. Shi, Ch. Chen, D. Mah, and M. Chan, “Monte-Carlo calculation of the mass stopping power of EBT3 and EBT-XD films for protons for energy ranges of 50–400 MeV,” Precis. Radiat. Oncol. 2, 106–113 (2018).

    Article  Google Scholar 

  32. P. Lansonneur, V. Favaudon, et al., “Simulation and experimental validation of a prototype electron beam linear accelerator for preclinical studies,” Phys. Med. 60, 50–57 (2019).

    Article  Google Scholar 

  33. E. Y. Leon-Marroquin, D. Murlow, A. Darafsaheh, and R. Khan, “Response characterization of EBT-XD radiochromic films in megavoltage photon and electron beams,” Med. Phys. 46, 4246–4256 (2019).

    Article  Google Scholar 

  34. S. Yonai, C. H. Arai, K. Shimoyama, and N. Fournier-Bidoz, “Experimental evaluation of dosimetric characterization of Gafchromic EBT3 and EBT-XD films for clinical carbon ion beams,” Radiat. Prot. Dosim. 180, 314–318 (2018).

    Article  Google Scholar 

  35. A. Niroomand-Rad, Cr. Blackwell, et al., “Radiochromic film dosimetry: Recommendations of AAPM radiation committee task group 55: American association of physicists in medicine,” Med. Phys. 25, 2093–2115 (1998); Report No 63.

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ACKNOWLEDGMENTS

The authors wish to thank Bradley Londres for his assistance in editing and improving the text.

Funding

This research was funded by National Science Center (grant no. 2015/19/B/NZ7/03811).

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Authors and Affiliations

  1. Department of Medical Physics, Greater Poland Cancer Centre, 61-688, Poznan, Poland

    D. M. Borowicz, M. Kruszyna-Mochalska & J. Malicki

  2. Laboratory of Nuclear Problems, Joint Institute for Nuclear Research, 141980, Dubna, Moscow region, Russia

    K. Shipulin, A. Molokanov & G. Mytsin

  3. Electroradiology Department, University of Medical Sciences, 61-688, Poznan, Poland

    M. Kruszyna-Mochalska & J. Malicki

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  1. D. M. Borowicz
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Correspondence to D. M. Borowicz.

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Borowicz, D.M., Kruszyna-Mochalska, M., Shipulin, K. et al. Comparison of Dose–Response Curves between EBT-XD and EBT3 Radiochromic Films at High Dose Range (2000–4500 cGy) for a 175 MeV Proton Beam. Phys. Part. Nuclei Lett. 18, 691–699 (2021). https://doi.org/10.1134/S1547477121060030

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