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Evaluation of Radiation-Induced Damage in Membrane Ion Channels and Synaptic Receptors

  • RADIOBIOLOGY, ECOLOGY AND NUCLEAR MEDICINE
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Abstract

The study of irradiation of brain cells with exposure to accelerated charged particles is essential topic in modern radiobiological research. Using Geant4-DNA based Monte-Carlo simulation of particle tracks we studied initial energy deposition and radiolytic species production within critical targets on neural cells: voltage-gated membrane channels and synaptic receptors. According to the modeling results the most probable targets for radiation damage can be attributed to synaptic receptors of GABA and NMDA type rather than ion channels. Indirect damage caused by chemical interaction with free radicals dominates over direct ionization events. We also provide an estimation for damage induction efficiency after the exposure with particles of different dose and linear energy transfer.

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ACKNOWLEDGMENTS

This work was conducted as part of the joint research between the Laboratory of Radiation Biology of JINR and the National University of Mongolia. The authors also acknowledge financial support of Russian Foundation for Basic Research (grant no. 17-29-01007).

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Authors and Affiliations

  1. Joint Institute for Nuclear Research, 141980, Dubna, Russia

    L. Bayarchimeg, M. Batmunkh & A. N. Bugay

  2. National University of Mongolia, 14201, Ulaanbaatar, Mongolia

    O. Lkhagva

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  1. L. Bayarchimeg
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  2. M. Batmunkh
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Correspondence to A. N. Bugay.

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Bayarchimeg, L., Batmunkh, M., Bugay, A.N. et al. Evaluation of Radiation-Induced Damage in Membrane Ion Channels and Synaptic Receptors. Phys. Part. Nuclei Lett. 16, 54–62 (2019). https://doi.org/10.1134/S1547477119010059

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