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Mouse retinal adaptive response to proton irradiation: Correlation with DNA repair and photoreceptor cell death

  • Radiobiology, Ecology and Nuclear Medicine
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Abstract

Emerging body of data indicate protecting effect of low level of stress (preconditioning) on retina. Our previous study revealed non-linear dose-response relationship for cytotoxicity of both ionizing radiation and N-methyl-N-nitrosourea (MNU) on mouse retina. Moreover, non cytotoxic dose of MNU increased tolerance of retina to following challenge dose of MNU. This result displays protection of retina through mechanism of recovery. In present study we used the mouse model for MNU-induced retinal degeneration to evaluate adaptive response of retina to proton irradiation and implication in it of glial Muller cells. The data showed that the recovery of retina after genotoxic agents has been associated with increased efficacy of DNA damage repair and lowered death of retinal photoreceptor cells.

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Authors and Affiliations

  1. Semenov Institute of Chemical Physics, Russian Academy of Sciences, Moscow, Russia

    V. A. Tronov

  2. Joint Institute for Nuclear Research, Dubna, Moscow oblast, Russia

    V. A. Tronov, Yu. V. Vinogradova & M. A. Ostrovsky

  3. Koltsov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, Russia

    V. A. Poplinskaya

  4. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow, Russia

    E. I. Nekrasova & M. A. Ostrovsky

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  1. V. A. Tronov
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  2. Yu. V. Vinogradova
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  4. E. I. Nekrasova
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Correspondence to Yu. V. Vinogradova.

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Original Russian Text © V.A. Tronov, Yu.V. Vinogradova, V.A. Poplinskaya, E.I. Nekrasova, M.A. Ostrovsky, 2015, published in Pis’ma v Zhurnal Fizika Elementarnykh Chastits i Atomnogo Yadra, 2015.

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Tronov, V.A., Vinogradova, Y.V., Poplinskaya, V.A. et al. Mouse retinal adaptive response to proton irradiation: Correlation with DNA repair and photoreceptor cell death. Phys. Part. Nuclei Lett. 12, 173–183 (2015). https://doi.org/10.1134/S1547477115010227

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